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Literature DB >> 9528843

Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity.

C H Köhne¹, P Thuss-Patience, M Friedrich, P T Daniel, A Kretzschmar, T Benter, B Bauer, R Dietz, B Dörken.

Abstract

Two patients with proven 5-fluorouracil (5-FU)-associated cardiotoxicity were treated with the specific thymidylate synthase inhibitor raltitrexed safely, without evidence of cardiotoxicity. Raltitrexed might be an alternative for patients with advanced colorectal cancer and 5-FU-associated cardiotoxicity. 5-FU cardiotoxicity is not due to the antineoplastic mechanisms via thymidilate synthase.

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Year: 1998 PMID： 9528843 PMCID： PMC2150099 DOI： 10.1038/bjc.1998.160

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

16 in total

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9 in total

Review 1. Cardiotoxicity of the antiproliferative compound fluorouracil.

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Authors: Carlos Eduardo Paiva; Bianca Sakamoto Ribeiro Paiva; Rodrigo Garita; Odair Carlito Michelin; Katashi Okoshi
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Authors: Christina Leah B Kline; Wafik S El-Deiry
Journal: Pharmaceuticals (Basel) Date: 2013-08-21

5. 2-Amino-4,5-dihydrothiophene-3-carbonitriles: A New Synthesis, Quantum Chemical Studies, and Mannich-Type Reactions Leading to New Hexahydrothieno[2,3-d]pyrimidines.

Authors: Victor V Dotsenko; Alexander V Bespalov; Arthur S Vashurin; Nicolai A Aksenov; Inna V Aksenova; Elena A Chigorina; Sergey G Krivokolysko
Journal: ACS Omega Date: 2021-11-19

6. Biweekly Raltitrexed Combined With Irinotecan as Second-Line Therapy for Patients With Metastatic Colorectal Cancer: A Phase II Trial.

Authors: Ke Cheng; Yu-Wen Zhou; Ye Chen; Zhi-Ping Li; Meng Qiu; Ji-Yan Liu
Journal: Cancer Control Date: 2022 Jan-Dec Impact factor: 3.302