Literature DB >> 9527811

Critical importance of in vivo amoxicillin and cefotaxime concentrations for synergy in treatment of experimental Enterococcus faecalis endocarditis.

O Join-Lambert1, J L Mainardi, C Cuvelier, S Dautrey, R Farinotti, B Fantin, C Carbon.   

Abstract

The synergy between amoxicillin and cefotaxime against two strains of Enterococcus faecalis (JH2-2 and 6370) in vitro and in rabbit endocarditis was investigated. In vitro synergy was obtained only when amoxicillin concentrations were below the MBC and when cefotaxime concentrations were above 1 microg/ml. No synergy was observed in vivo, because of the short period of time during which these pharmacologic requirements were achieved.

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Year:  1998        PMID： 9527811      PMCID： PMC105439          DOI： 10.1128/AAC.42.2.468

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  8 in total

Review 1.  High-performance liquid chromatography of antibiotics.

Authors:  F Jehl; C Gallion; H Monteil
Journal:  J Chromatogr       Date:  1990-10-12

2.  Selection of glycopeptide-resistant mutants of VanB-type Enterococcus faecalis BM4281 in vitro and in experimental endocarditis.

Authors:  E Aslangul; M Baptista; B Fantin; F Depardieu; M Arthur; P Courvalin; C Carbon
Journal:  J Infect Dis       Date:  1997-03       Impact factor: 5.226

3.  Susceptibility of group D streptococcus (enterococcus) to 21 antibiotics in vitro, with special reference to species differences.

Authors:  P Toala; A McDonald; C Wilcox; M Finland
Journal:  Am J Med Sci       Date:  1969-12       Impact factor: 2.378

4.  In vitro response to bactericidal activity of cell wall-active antibiotics does not support the general opinion that enterococci are naturally tolerant to these antibiotics.

Authors:  R Fontana; A Grossato; M Ligozzi; E A Tonin
Journal:  Antimicrob Agents Chemother       Date:  1990-08       Impact factor: 5.191

5.  Method of reliable determination of minimal lethal antibiotic concentrations.

Authors:  R D Pearson; R T Steigbigel; H T Davis; S W Chapman
Journal:  Antimicrob Agents Chemother       Date:  1980-11       Impact factor: 5.191

6.  Synergistic effect of amoxicillin and cefotaxime against Enterococcus faecalis.

Authors:  J L Mainardi; L Gutmann; J F Acar; F W Goldstein
Journal:  Antimicrob Agents Chemother       Date:  1995-09       Impact factor: 5.191

7.  Influence of the developmental state of valvular lesions on the antimicrobial activity of cefotaxime in experimental enterococcal infections.

Authors:  P M Sullam; T A Drake; M G Täuber; C J Hackbarth; M A Sande
Journal:  Antimicrob Agents Chemother       Date:  1985-03       Impact factor: 5.191

8.  Pharmacokinetics of cephalosporins in normal and septicemic rabbits.

Authors:  U Ganzinger; A Haslberger
Journal:  Antimicrob Agents Chemother       Date:  1985-10       Impact factor: 5.191
  8 in total
  3 in total

1.  Activity of LY333328 combined with gentamicin in vitro and in rabbit experimental endocarditis due to vancomycin-susceptible or -resistant Enterococcus faecalis.

Authors:  A Lefort; A Saleh-Mghir; L Garry; C Carbon; B Fantin
Journal:  Antimicrob Agents Chemother       Date:  2000-11       Impact factor: 5.191

2.  Bactericidal synergism between antibiotics and phage endolysin Cpl-711 to kill multidrug-resistant pneumococcus.

Authors:  Patricia Letrado; Bruno Corsini; Roberto Díez-Martínez; Noemí Bustamante; José E Yuste; Pedro García
Journal:  Future Microbiol       Date:  2018-09-21       Impact factor: 3.165

3.  In vitro Antimicrobial Activity of Ampicillin-Ceftriaxone and Ampicillin-Ertapenem Combinations Against Clinical Isolates of Enterococcus faecalis with High Levels of Aminoglycoside Resistance.

Authors:  Maria Bruna Pasticci; Antonella Mencacci; Amedeo Moretti; Nicola Palladino; Luigi Maria Lapalorcia; Francesco Bistoni; Franco Baldelli
Journal:  Open Microbiol J       Date:  2008-06-09
  3 in total

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