Literature DB >> 9527477

High throughput analysis and purification in support of automated parallel synthesis.

H N Weller1, M G Young, S J Michalczyk, G H Reitnauer, R S Cooley, P C Rahn, D J Loyd, D Fiore, S J Fischman.   

Abstract

Rapid reverse-phase analytical and preparative HPLC methods have been developed for application to parallel synthesis libraries. Gradient methods, short columns, and high flow rates allow analysis of over 300 compounds per day on a single system, or purification of up to 200 compounds per day on a single preparative system. Hardware and software modifications allow continuous unattended use for maximum efficiency and throughput.

Mesh：

Year:  1997        PMID： 9527477     DOI： 10.1023/a:1009636725336

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  8 in total

1.  Synthesis and Applications of Small Molecule Libraries.

Authors:  Lorin A. Thompson; Jonathan A. Ellman
Journal:  Chem Rev       Date:  1996-02-01       Impact factor: 60.622

2.  Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery.

Authors:  R A Houghten; C Pinilla; S E Blondelle; J R Appel; C T Dooley; J H Cuervo
Journal:  Nature       Date:  1991-11-07       Impact factor: 49.962

3.  A new type of synthetic peptide library for identifying ligand-binding activity.

Authors:  K S Lam; S E Salmon; E M Hersh; V J Hruby; W M Kazmierski; R J Knapp
Journal:  Nature       Date:  1991-11-07       Impact factor: 49.962

4.  Complex synthetic chemical libraries indexed with molecular tags.

Authors:  M H Ohlmeyer; R N Swanson; L W Dillard; J C Reader; G Asouline; R Kobayashi; M Wigler; W C Still
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-01       Impact factor: 11.205

Review 5.  Encoding methods for combinatorial chemistry.

Authors:  A W Czarnik
Journal:  Curr Opin Chem Biol       Date:  1997-06       Impact factor: 8.822

Review 6.  Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries.

Authors:  M A Gallop; R W Barrett; W J Dower; S P Fodor; E M Gordon
Journal:  J Med Chem       Date:  1994-04-29       Impact factor: 7.446

7.  Two new criteria for choosing sample size in combinatorial chemistry.

Authors:  P L Zhao; R B Nachbar; J A Bolognese; K Chapman
Journal:  J Med Chem       Date:  1996-01-19       Impact factor: 7.446

8.  Versatile approach to encoding combinatorial organic syntheses using chemically robust secondary amine tags.

Authors:  Z J Ni; D Maclean; C P Holmes; M M Murphy; B Ruhland; J W Jacobs; E M Gordon; M A Gallop
Journal:  J Med Chem       Date:  1996-04-12       Impact factor: 7.446
  8 in total
  1 in total

1.  Fluorous mixture synthesis of two libraries with hydantoin-, and benzodiazepinedione-fused heterocyclic scaffolds.

Authors:  Wei Zhang; Yimin Lu; Christine Hiu-Tung Chen; Lu Zeng; Daniel B Kassel
Journal:  J Comb Chem       Date:  2006 Sep-Oct
  1 in total

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