Literature DB >> 9526841

Expression of the CB1 cannabinoid receptor in macrophage-like cells from brain tissue: immunochemical characterization by fusion protein antibodies.

D Sinha1, T I Bonner, N R Bhat, L A Matsuda.   

Abstract

Antibodies designed to recognize a 74 amino acid sequence of the N- or C-terminal domain of the rat CB1 cannabinoid receptor detected a 58 kDa protein in immunoblots of brain and various cells known to express the CB1 cannabinoid receptor. A human B-lymphoblastoid cell line and macrophage-like cells from neonatal rat brain were also positive for CB1 receptor-like immunoreactivity. Immunocytochemical analysis performed with isolated Fab fragments showed surface staining in NG108-15 cells and brain macrophage like cells which also express MHC class II antigens. The data suggest a plausible role for CB1 receptors in the immune function of brain.

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Year:  1998        PMID： 9526841     DOI： 10.1016/s0165-5728(97)00181-1

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  13 in total

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Review 7.  CB2 receptors in the brain: role in central immune function.

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Review 8.  Cannabinoids and neuroinflammation.

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Review 9.  Neuroimmune interactions and pain: focus on glial-modulating targets.

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10.  WIN55,212-2-mediated inhibition of HIV-1 expression in microglial cells: involvement of cannabinoid receptors.

Authors:  R Bryan Rock; Genya Gekker; Shuxian Hu; Wen S Sheng; Guy A Cabral; Billy R Martin; Phillip K Peterson
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