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Literature DB >> 9526541

Vaccine efficacy of recombinant feline herpesvirus type 1 expressing immunogenic proteins of feline calicivirus in cats.

N Yokoyama¹, K Maeda, K Fujita, S Ishiguro, T Sagawa, M Mochizuki, Y Tohya, T Mikami.

Abstract

We previously constructed a recombinant feline herpesvirus type 1 (FHV1), C7301dlTK-Cap, which contains an entire open reading frame encoding the capsid protein of feline calicivirus (FCV) F4 strain in the deleted locus of the thymidine kinase (TK) deficient mutant (C7301dlTK) of FHV1. In this report, we carried out in vivo experiments to assess the vaccine efficacy of the recombinant C7301dlTK-Cap against FCV and FHV1 infections in cats. As a result, two vaccinations with the C7301dlTK-Cap by intraocular, intranasal and oral routes protected cats to a significant degree against subsequent virulent challenges with both parent FCV F4 and FHV1 C7301 strains. The results are applicable for the further development of a new genetically engineered polyvalent vaccine for cats.

Entities: Disease Species

Mesh：

Substances：

Year: 1996 PMID： 9526541 DOI： 10.1007/bf01718635

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

35 in total

1. A survey of feline viral upper respiratory tract infections.

Authors: N J MacLachlan; G W Burgess
Journal: N Z Vet J Date: 1978-10 Impact factor: 1.628

2. Nucleotide sequence of a region of the feline calicivirus genome which encodes picornavirus-like RNA-dependent RNA polymerase, cysteine protease and 2C polypeptides.

Authors: J D Neill
Journal: Virus Res Date: 1990-11 Impact factor: 3.303

3. Studies on cytopathogenic viruses from cats with respiratory infections. III. Isolation and certain properties of feline herpesviruses.

Authors: M Mochizuki; S Konishi; M Ogata
Journal: Nihon Juigaku Zasshi Date: 1977-02

Review 4. Infectious respiratory diseases of cats.

Authors: D E Kahn; E A Hoover
Journal: Vet Clin North Am Date: 1976-08

5. Feline respiratory tract disease in Louisiana.

Authors: S Bech-Nielsen; R W Fulton; H U Cox; J D Hoskins; J B Malone; R K McGrath
Journal: Am J Vet Res Date: 1980-08 Impact factor: 1.156

6. Neutralizing epitopes of feline calicivirus.

Authors: Y Tohya; K Masuoka; E Takahashi; T Mikami
Journal: Arch Virol Date: 1991 Impact factor: 2.574

7. In vivo properties of a feline herpesvirus type 1 mutant carrying a lacZ insertion at the gI locus of the unique short segment.

Authors: M J Willemse; W S Chalmers; P J Sondermeijer
Journal: Vaccine Date: 1996-01 Impact factor: 3.641

8. The molecular cloning and sequence of an open reading frame encoding for non-structural proteins of feline calicivirus F4 strain isolated in Japan.

Authors: R Oshikamo; Y Tohya; Y Kawaguchi; K Tomonaga; K Maeda; N Takeda; E Utagawa; C Kai; T Mikami
Journal: J Vet Med Sci Date: 1994-12 Impact factor: 1.267