| Literature DB >> 9526540 |
H Kariwa1, M Kimura, S Yoshizumi, J Arikawa, K Yoshimatsu, I Takashima, N Hashimoto.
Abstract
To understand the mode of persistent infection of Seoul virus in rodents, we examined the distribution of the virus genome and antibody production in infected rats. When 1-day-old rats were inoculated with the KI-83-262 strain, the S segment of viral genome was detected in sera, clots, lungs and kidneys from 3 to 184 days post inoculation (d.p.i.) by nested reverse transcriptase PCR. On the other hand, when 7-week-old rats were infected with this virus, viral genome was detected only in the lungs from 3 to 50 d.p.i. The neutralizing antibody titers of rats inoculated at 1-day of age were higher than those of rats inoculated at 7 weeks of age. In both age groups, however, the IgG avidity of antibody increased along with the course of infection. We found that urban rats (Rattus norvegicus) infected early in life harbored the virus for more than 6 months.Entities:
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Year: 1996 PMID： 9526540 DOI： 10.1007/bf01718634
Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574