Literature DB >> 9525699

Lessons from TGF-beta transgenic mice.

E P Böttinger1, J B Kopp.   

Abstract

Aberrant expression of TGF-beta and/or receptor/signaling function is present in a wide variety of disease processes. Overexpression of TGF-beta isoforms in transgenic mice using tissue-specific promoters has provided model systems to study the effects of increased activity of TGF-beta in the intact organism. We will review the pertinent features of some of these models, and discuss new insights provided by these studies into regulation and role of TGF-beta in health and disease.

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Year:  1998        PMID： 9525699     DOI： 10.1159/000057364

Source DB:  PubMed          Journal:  Miner Electrolyte Metab        ISSN： 0378-0392


  7 in total

1.  TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis.

Authors:  Leslie Gewin; Nada Bulus; Glenda Mernaugh; Gilbert Moeckel; Raymond C Harris; Harold L Moses; Ambra Pozzi; Roy Zent
Journal:  J Am Soc Nephrol       Date:  2010-06-24       Impact factor: 10.121

2.  Transgenic expression of TGF-beta on thyrocytes inhibits development of spontaneous autoimmune thyroiditis and increases regulatory T cells in thyroids of NOD.H-2h4 mice.

Authors:  Shiguang Yu; Yujiang Fang; Gordon C Sharp; Helen Braley-Mullen
Journal:  J Immunol       Date:  2010-03-24       Impact factor: 5.422

3.  Alteration of transforming growth factor-beta1 response involves down-regulation of Smad3 signaling in myofibroblasts from skin fibrosis.

Authors:  P Reisdorf; D A Lawrence; V Sivan; E Klising; M T Martin
Journal:  Am J Pathol       Date:  2001-07       Impact factor: 4.307

4.  Invariant natural killer T cells and TGF-beta attenuate anti-GBM glomerulonephritis.

Authors:  Laurent Mesnard; Alexandre C Keller; Marie-Laure Michel; Sophie Vandermeersch; Cédric Rafat; Emmanuel Letavernier; Yves Tillet; Eric Rondeau; Maria C Leite-de-Moraes
Journal:  J Am Soc Nephrol       Date:  2009-05-21       Impact factor: 10.121

5.  MicroRNA-21 in glomerular injury.

Authors:  Jennifer Y Lai; Jinghui Luo; Christopher O'Connor; Xiaohong Jing; Viji Nair; Wenjun Ju; Ann Randolph; Iddo Z Ben-Dov; Regina N Matar; Daniel Briskin; Jiri Zavadil; Robert G Nelson; Thomas Tuschl; Frank C Brosius; Matthias Kretzler; Markus Bitzer
Journal:  J Am Soc Nephrol       Date:  2014-08-21       Impact factor: 10.121

Review 6.  Molecular targets for treatment of kidney fibrosis.

Authors:  Peter Y Chuang; Madhav C Menon; John C He
Journal:  J Mol Med (Berl)       Date:  2012-11-22       Impact factor: 4.599

7.  Bmi-1 plays a critical role in protection from renal tubulointerstitial injury by maintaining redox balance.

Authors:  Jianliang Jin; Xianhui Lv; Lulu Chen; Wei Zhang; Jinbo Li; Qian Wang; Rong Wang; Xiang Lu; Dengshun Miao
Journal:  Aging Cell       Date:  2014-06-11       Impact factor: 9.304
  7 in total

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