Literature DB >> 9525667

Enhancement of aquareovirus infectivity by treatment with proteases: mechanism of action.

T H McPhillips1, D Dinan, K Subramanian, S K Samal.   

Abstract

The effects of protease digestion on the polypeptide composition and on the infectivity of striped bass virus, an aquareovirus, were examined. Both trypsin and chymotrypsin enhanced the infectivity of the virus. Enhancement of infectivity was correlated with the digestion of the outer capsid protein, VP7. These studies support the assertion that VP7 is the outermost capsid protein and suggest that VP4 and VP5 are exposed on the outer surface of infectious particles. The possible role of VP7 in the variation in virulence observed among aquareovirus isolates is discussed.

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Year:  1998        PMID： 9525667      PMCID： PMC109827     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  12 in total

Review 1.  Mechanisms of viral pathogenesis. Distinct forms of reoviruses and their roles during replication in cells and host.

Authors:  M L Nibert; D B Furlong; B N Fields
Journal:  J Clin Invest       Date:  1991-09       Impact factor: 14.808

2.  Proteolytic enhancement of rotavirus infectivity: biology mechanism.

Authors:  D Y Graham; M K Estes
Journal:  Virology       Date:  1980-03       Impact factor: 3.616

3.  The structure of aquareovirus shows how the different geometries of the two layers of the capsid are reconciled to provide symmetrical interactions and stabilization.

Authors:  A L Shaw; S K Samal; K Subramanian; B V Prasad
Journal:  Structure       Date:  1996-08-15       Impact factor: 5.006

4.  Studies on the effect of chymotrypsin on reovirions.

Authors:  W K Joklik
Journal:  Virology       Date:  1972-09       Impact factor: 3.616

5.  Genetic analysis of aquareoviruses using RNA-RNA blot hybridization.

Authors:  B Lupiani; F M Hetrick; S K Samal
Journal:  Virology       Date:  1993-11       Impact factor: 3.616

6.  Proteolytic enhancement of rotavirus infectivity: molecular mechanisms.

Authors:  M K Estes; D Y Graham; B B Mason
Journal:  J Virol       Date:  1981-09       Impact factor: 5.103

7.  Structural polypeptides of simian rotavirus SA11 and the effect of trypsin.

Authors:  R T Espejo; S López; C Arias
Journal:  J Virol       Date:  1981-01       Impact factor: 5.103

8.  Enhancement of reovirus infectivity by extracellular removal or alteration of the virus capsid by proteolytic enzymes.

Authors:  R S Spendlove; M E McClain; E H Lennette
Journal:  J Gen Virol       Date:  1970-08       Impact factor: 3.891

9.  Molecular characterization of a rotaviruslike virus isolated from striped bass (Morone saxatilis).

Authors:  S K Samal; C P Dopazo; T H McPhillips; A Baya; S B Mohanty; F M Hetrick
Journal:  J Virol       Date:  1990-11       Impact factor: 5.103

10.  New intermediate subviral particles in the in vitro uncoating of reovirus virions by chymotrypsin.

Authors:  J Borsa; T P Copps; M D Sargent; D G Long; J D Chapman
Journal:  J Virol       Date:  1973-04       Impact factor: 5.103
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  7 in total

Review 1.  Viruses of lower vertebrates.

Authors:  S Essbauer; W Ahne
Journal:  J Vet Med B Infect Dis Vet Public Health       Date:  2001-08

2.  Trypsin-induced structural transformation in aquareovirus.

Authors:  E L Nason; S K Samal; B V Venkataram Prasad
Journal:  J Virol       Date:  2000-07       Impact factor: 5.103

3.  Molecular Characterization of Outer Capsid Proteins VP5 and VP7 of Grass Carp Reovirus.

Authors:  Fuxian Zhang; Diangang Sun; Qin Fang
Journal:  Viruses       Date:  2022-05-12       Impact factor: 5.818

4.  Molecular cloning, DNA sequence analysis, and expression of cDNA sequence of RNA genomic segment 6 (S6) that encodes a viral outer capsid protein of threadfin aquareovirus (TFV).

Authors:  Eng Khuan Seng; Qin Fang; Yoke Min Sin; Toong Jin Lam
Journal:  Virus Genes       Date:  2005-03       Impact factor: 2.332

5.  Corexit 9500 inactivates two enveloped viruses of aquatic animals but enhances the infectivity of a nonenveloped fish virus.

Authors:  P H Pham; Y J Huang; C Chen; N C Bols
Journal:  Appl Environ Microbiol       Date:  2013-11-22       Impact factor: 4.792

6.  Antibodies against outer-capsid proteins of grass carp reovirus expressed in E. coli are capable of neutralizing viral infectivity.

Authors:  Ling Shao; Xiaoyun Sun; Qin Fang
Journal:  Virol J       Date:  2011-07-12       Impact factor: 4.099

7.  Aquareovirus NS80 recruits viral proteins to its inclusions, and its C-terminal domain is the primary driving force for viral inclusion formation.

Authors:  Ling Shao; Hong Guo; Li-Ming Yan; Huan Liu; Qin Fang
Journal:  PLoS One       Date:  2013-02-12       Impact factor: 3.240
  7 in total

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