Literature DB >> 9524132

Nuclear history of a pre-mRNA determines the translational activity of cytoplasmic mRNA.

K Matsumoto1, K M Wassarman, A P Wolffe.   

Abstract

The pathways of synthesis and maturation of pre-messenger RNA in the nucleus have a direct effect on the translational efficiency of mRNA in the cytoplasm. The transcription of intron-less mRNA in vivo directs this mRNA towards translational silencing. The presence of an intron at the 5' end of the transcript relieves this silencing, whereas an intron at the 3' end further represses translation. These regulatory events are strongly dependent on the transcription of pre-mRNA in the nucleus. The impact of nuclear history on regulatory events in the cytoplasm provides a novel mechanism for the control of gene expression.

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Year:  1998        PMID： 9524132      PMCID： PMC1170555          DOI： 10.1093/emboj/17.7.2107

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  91 in total

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Authors:  H Mehlin; B Daneholt; U Skoglund
Journal:  Cell       Date:  1992-05-15       Impact factor: 41.582

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Journal:  Curr Opin Cell Biol       Date:  1991-12       Impact factor: 8.382

6.  In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism.

Authors:  L F Jiménez-García; D L Spector
Journal:  Cell       Date:  1993-04-09       Impact factor: 41.582

7.  Demonstration of a 7-nm RNP fiber as the basic structural element in a premessenger RNP particle.

Authors:  A Lönnroth; K Alexciev; H Mehlin; T Wurtz; U Skoglund; B Daneholt
Journal:  Exp Cell Res       Date:  1992-04       Impact factor: 3.905

8.  The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6.U5 small nuclear ribonucleoprotein in spliceosome assembly.

Authors:  J Kjems; P A Sharp
Journal:  J Virol       Date:  1993-08       Impact factor: 5.103

9.  Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm.

Authors:  S Piñol-Roma; G Dreyfuss
Journal:  Nature       Date:  1992-02-20       Impact factor: 49.962

10.  Histone H4 acetylation and transcription in amphibian chromatin.

Authors:  J Sommerville; J Baird; B M Turner
Journal:  J Cell Biol       Date:  1993-01       Impact factor: 10.539
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  76 in total

1.  The Y14 protein communicates to the cytoplasm the position of exon-exon junctions.

Authors:  V N Kim; J Yong; N Kataoka; L Abel; M D Diem; G Dreyfuss
Journal:  EMBO J       Date:  2001-04-17       Impact factor: 11.598

Review 2.  mRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization?

Authors:  P Hilleren; R Parker
Journal:  RNA       Date:  1999-06       Impact factor: 4.942

3.  UBP1, a novel hnRNP-like protein that functions at multiple steps of higher plant nuclear pre-mRNA maturation.

Authors:  M H Lambermon; G G Simpson; D A Wieczorek Kirk; M Hemmings-Mieszczak; U Klahre; W Filipowicz
Journal:  EMBO J       Date:  2000-04-03       Impact factor: 11.598

4.  Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions.

Authors:  H Le Hir; M J Moore; L E Maquat
Journal:  Genes Dev       Date:  2000-05-01       Impact factor: 11.361

5.  Structure and expression of the human p68 RNA helicase gene.

Authors:  O G Rössler; P Hloch; N Schütz; T Weitzenegger; H Stahl
Journal:  Nucleic Acids Res       Date:  2000-02-15       Impact factor: 16.971

6.  Design of 5' untranslated sequences in retroviral vectors developed for medical use.

Authors:  M Hildinger; K L Abel; W Ostertag; C Baum
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

7.  The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.

Authors:  H Le Hir; D Gatfield; E Izaurralde; M J Moore
Journal:  EMBO J       Date:  2001-09-03       Impact factor: 11.598

8.  Introns and their positions affect the translational activity of mRNA in plant cells.

Authors:  V Bourdon; A Harvey; D M Lonsdale
Journal:  EMBO Rep       Date:  2001-05       Impact factor: 8.807

9.  Requirements for intron-mediated enhancement of gene expression in Arabidopsis.

Authors:  Alan B Rose
Journal:  RNA       Date:  2002-11       Impact factor: 4.942

10.  Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK.

Authors:  John H Coyle; Brian W Guzik; Yeou-Cherng Bor; Li Jin; Lucia Eisner-Smerage; Stephen J Taylor; David Rekosh; Marie-Louise Hammarskjöld
Journal:  Mol Cell Biol       Date:  2003-01       Impact factor: 4.272
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