Literature DB >> 9523289

Lenticular calcium, magnesium, and iron levels in diabetic rats and verapamil effect.

O Cekic1, Y Bardak.   

Abstract

Lenticular calcium (Ca), magnesium (Mg), and iron (Fe) changes in diabetic rats and the effects of the Ca antagonist drug verapamil on this electrolyte imbalance were studied. Verapamil administration had no effect on the blood glucose values. Compared to the control group, a significant increase was observed in the lenticular Ca, Mg, and Fe content of the diabetic rats. Eight weeks of verapamil administration to the diabetic animals significantly reduced lenticular Ca, Mg, Fe values. Therefore it is suggested that verapamil might be a useful drug to prevent diabetic cataract formation.

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Year:  1998        PMID： 9523289     DOI： 10.1159/000055462

Source DB:  PubMed          Journal:  Ophthalmic Res        ISSN： 0030-3747            Impact factor:   2.892


  6 in total

1.  Effect of verapamil on lenticular calcium, magnesium and iron in radiation exposed rats.

Authors:  Y Bardak; O Cekiç; Y Totan; M Cengiz
Journal:  Int Ophthalmol       Date:  1998       Impact factor: 2.031

2.  Effect of methanolic extract of Allium sativum (AS) in delaying cataract in STZ-induced diabetic rats.

Authors:  T Naga Raju; V Rajani Kanth; K Lavanya
Journal:  J Ocul Biol Dis Infor       Date:  2008-07-19

3.  Verapamil reverses cardiac iron overload in streptozocin-induced diabetic rats.

Authors:  Hong-li Shan; Yan Wang; Jian-wei Wu; Peng-zhou Hang; Xin Li; Li-hua Sun; Jian-cui Qi; Yu-ying Mao; Zhi-dan Sun; Zhi-min Du
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2013-04-07       Impact factor: 3.000

4.  L-type calcium channels play a critical role in maintaining lens transparency by regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins.

Authors:  Rupalatha Maddala; Tharkika Nagendran; Gustaaf G de Ridder; Kevin L Schey; Ponugoti Vasantha Rao
Journal:  PLoS One       Date:  2013-05-29       Impact factor: 3.240

5.  A Genome-Wide Association Study Provides New Evidence That CACNA1C Gene is Associated With Diabetic Cataract.

Authors:  Cheng Chang; Kaida Zhang; Abirami Veluchamy; Harry L Hébert; Helen C Looker; Helen M Colhoun; Colin N A Palmer; Weihua Meng
Journal:  Invest Ophthalmol Vis Sci       Date:  2016-04-01       Impact factor: 4.799

6.  Instillation of Ophthalmic Formulation Containing Nilvadipine Nanocrystals Attenuates Lens Opacification in Shumiya Cataract Rats.

Authors:  Ryoka Goto; Shigehiro Yamada; Hiroko Otake; Yosuke Nakazawa; Mikako Oka; Naoki Yamamoto; Hiroshi Sasaki; Noriaki Nagai
Journal:  Pharmaceutics       Date:  2021-11-25       Impact factor: 6.321
  6 in total

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