Literature DB >> 9523110

Role of the bactericidal/permeability-increasing protein in host defence.

P Elsbach1, J Weiss.   

Abstract

Much has been learned recently about the structure and function of 55 kDa bactericidal/permeability-increasing protein (BPI), a member of a genomically conserved lipid-interactive protein family. Analysis of BPI fragments and the crystal structure of human BPI have established that BPI consists of two functionally distinct domains: a potently antibacterial and anti-endotoxin amino-terminal domain (approximately 20 kDa) and a carboxy-terminal portion that imparts opsonic activity to BPI. A recombinant amino-terminal fragment (rBPI21) protects animals against the effects of Gram-negative bacteria and endotoxin. In man, rBPI21 is nontoxic and non-immunogenic and is in Phase II/III clinical trials with apparent therapeutic benefit.

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Year:  1998        PMID： 9523110     DOI： 10.1016/s0952-7915(98)80030-7

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  53 in total

Review 1.  A neutrophil-derived anti-infective molecule: bactericidal/permeability-increasing protein.

Authors:  O Levy
Journal:  Antimicrob Agents Chemother       Date:  2000-11       Impact factor: 5.191

Review 2.  The role of antimicrobial peptides in animal defenses.

Authors:  R E Hancock; M G Scott
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-01       Impact factor: 11.205

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Authors:  Lina Lukinskiene; Yang Liu; Susan D Reynolds; Chad Steele; Barry R Stripp; George D Leikauf; Jay K Kolls; Y Peter Di
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Review 4.  Antimicrobial aspects of inflammatory resolution in the mucosa: a role for proresolving mediators.

Authors:  Eric L Campbell; Charles N Serhan; Sean P Colgan
Journal:  J Immunol       Date:  2011-10-01       Impact factor: 5.422

Review 5.  The immunopathogenesis of meningococcal disease.

Authors:  A J Kvalsvig; D J Unsworth
Journal:  J Clin Pathol       Date:  2003-06       Impact factor: 3.411

Review 6.  [Endotoxins. Pathogenetic meaning of sepsis].

Authors:  H Rensing
Journal:  Anaesthesist       Date:  2003-12       Impact factor: 1.041

7.  Acute-phase concentrations of lipopolysaccharide (LPS)-binding protein inhibit innate immune cell activation by different LPS chemotypes via different mechanisms.

Authors:  Lutz Hamann; Christian Alexander; Cordula Stamme; Ulrich Zähringer; Ralf R Schumann
Journal:  Infect Immun       Date:  2005-01       Impact factor: 3.441

8.  rBPI(21) promotes lipopolysaccharide aggregation and exerts its antimicrobial effects by (hemi)fusion of PG-containing membranes.

Authors:  Marco M Domingues; Miguel A R B Castanho; Nuno C Santos
Journal:  PLoS One       Date:  2009-12-22       Impact factor: 3.240

9.  SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection.

Authors:  Yang Liu; Jennifer A Bartlett; Marissa E Di; Jennifer M Bomberger; Yvonne R Chan; Lokesh Gakhar; Rama K Mallampalli; Paul B McCray; Y Peter Di
Journal:  Am J Pathol       Date:  2013-03-15       Impact factor: 4.307

10.  Fold-unfold transitions in the selectivity and mechanism of action of the N-terminal fragment of the bactericidal/permeability-increasing protein (rBPI(21)).

Authors:  Marco M Domingues; Sílvia C D N Lopes; Nuno C Santos; Alexandre Quintas; Miguel A R B Castanho
Journal:  Biophys J       Date:  2009-02       Impact factor: 4.033
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