Literature DB >> 9521925

Software for constructing and verifying pedigrees within large genealogies and an application to the Old Order Amish of Lancaster County.

R Agarwala1, L G Biesecker, K A Hopkins, C A Francomano, A A Schaffer.   

Abstract

This paper describes PedHunter, a software package that facilitates creation and verification of pedigrees within large genealogies. A frequent problem in medical genetics is to connect distant relatives with a pedigree. PedHunter uses methods from graph theory to solve two versions of the pedigree connection problem for genealogies as well as other pedigree analysis problems. The pedigrees are produced by PedHunter as files in LINKAGE format ready for linkage analysis. PedHunter uses a relational database of genealogy data, with tables in specified format, for all calculations. The functionality and utility of PedHunter are illustrated by examples using the Amish Genealogy Database (AGDB), which was created for the Old Order Amish community of Lancaster County, Pennsylvania.

Mesh：

Year:  1998        PMID： 9521925     DOI： 10.1101/gr.8.3.211

Source DB:  PubMed          Journal:  Genome Res        ISSN： 1088-9051            Impact factor:   9.043


  41 in total

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4.  Investigations of the Y chromosome, male founder structure and YSTR mutation rates in the Old Order Amish.

Authors:  Toni I Pollin; Daniel J McBride; Richa Agarwala; Alejandro A Schäffer; Alan R Shuldiner; Braxton D Mitchell; Jeffrey R O'Connell
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7.  Cognitive profiles and heritability estimates in the Old Order Amish.

Authors:  Ryan M Kuehner; Peter Kochunov; Katie L Nugent; Deanna E Jurius; Anya Savransky; Christopher Gaudiot; Heather A Bruce; James Gold; Alan R Shuldiner; Braxton D Mitchell; L Elliot Hong
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8.  PedHunter 2.0 and its usage to characterize the founder structure of the Old Order Amish of Lancaster County.

Authors:  Woei-Jyh Lee; Toni I Pollin; Jeffrey R O'Connell; Richa Agarwala; Alejandro A Schäffer
Journal:  BMC Med Genet       Date:  2010-05-02       Impact factor: 2.103

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10.  Phenotypic and genotypic data integration and exploration through a web-service architecture.

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