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Literature DB >> 9521881

Physical linkage of the human growth hormone gene cluster and the CD79b (Ig beta/B29) gene.

I M Bennani-Baïti¹, N E Cooke, S A Liebhaber.

Abstract

We have previously characterized a locus control region for the GH1 gene consisting of four DNase I hypersensitive sites (HS) located between 14.5 and 32 kb 5' to the GH1 gene transcription start site. Sequence analysis of the region between the GH1 gene and its most proximal HS (HSI) revealed a perfect match to the B-lymphocyte-specific CD79b gene. Restriction mapping and hybridization analysis of YAC and cosmid clones confirmed the close linkage of the CD79b gene to the hGH gene cluster and facilitated the assembly of a 100-kb physical map linking the hGH locus, the CD79b gene, and the more distant muscle-specific sodium channel alpha-subunit (SCN4A) gene.

Entities: Disease Gene Species

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Year: 1998 PMID： 9521881 DOI： 10.1006/geno.1997.5171

Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736

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Cited

16 in total

1. Patterns of histone acetylation suggest dual pathways for gene activation by a bifunctional locus control region.

Authors: F Elefant; Y Su; S A Liebhaber; N E Cooke
Journal: EMBO J Date: 2000-12-15 Impact factor: 11.598

2. DNase I hypersensitive site II of the human growth hormone locus control region mediates an essential and distinct long-range enhancer function.

Authors: Margaret R Fleetwood; Yugong Ho; Nancy E Cooke; Stephen A Liebhaber
Journal: J Biol Chem Date: 2012-06-05 Impact factor: 5.157

10. Differential placental hormone gene expression during pregnancy in a transgenic mouse containing the human growth hormone/chorionic somatomammotropin locus.

Authors: Y Jin; S Y Lu; A Fresnoza; K A Detillieux; M L Duckworth; P A Cattini
Journal: Placenta Date: 2009-01-24 Impact factor: 3.481

Physical linkage of the human growth hormone gene cluster and the CD79b (Ig beta/B29) gene.

1. Patterns of histone acetylation suggest dual pathways for gene activation by a bifunctional locus control region.

2. DNase I hypersensitive site II of the human growth hormone locus control region mediates an essential and distinct long-range enhancer function.

3. An RNA-independent linkage of noncoding transcription to long-range enhancer function.

4. Energy homeostasis targets chromosomal reconfiguration of the human GH1 locus.

5. Bystander gene activation by a locus control region.

6. Functional dissection of the mouse tyrosinase locus control region identifies a new putative boundary activity.

7. The juxtaposition of a promoter with a locus control region transcriptional domain activates gene expression.

8. Identification of a secondary promoter within the human B cell receptor component gene hCD79b.

9. A conserved sequence upstream of the B29 (Ig beta, CD79b) gene interacts with YY1.

10. Differential placental hormone gene expression during pregnancy in a transgenic mouse containing the human growth hormone/chorionic somatomammotropin locus.