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Literature DB >> 9519841

Effect of repeated oral infection of hamsters with scrapie.

Abstract

The development of a transmissible spongiform encephalopathy upon uptake of the infectious agent in feed was studied in the model system scrapie in hamsters. Compared to single dosing, repeated dosing caused disease at a considerable higher incidence. The risk of infection was higher when the time interval between repetitive dosing was short. There was a statistically significant trend of clearance of infectivity with time.

Entities: Disease

Mesh：

Year: 1998 PMID： 9519841 DOI： 10.1099/0022-1317-79-3-609

Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891

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Cited

23 in total

1. Rapid prion neuroinvasion following tongue infection.

Authors: Jason C Bartz; Anthony E Kincaid; Richard A Bessen
Journal: J Virol Date: 2003-01 Impact factor: 5.103

2. Identification of upregulated genes in scrapie-infected brain tissue.

Authors: C Riemer; I Queck; D Simon; R Kurth; M Baier
Journal: J Virol Date: 2000-11 Impact factor: 5.103

3. Repeated challenge with prion disease: the risk of infection and impact on incubation period.

Authors: Mike B Gravenor; Nigel Stallard; Robert Curnow; Angela R McLean
Journal: Proc Natl Acad Sci U S A Date: 2003-09-05 Impact factor: 11.205

4. Salivary prions in sheep and deer.

Authors: Gültekin Tamgüney; Jürgen A Richt; Amir N Hamir; Justin J Greenlee; Michael W Miller; Lisa L Wolfe; Tracey M Sirochman; Alan J Young; David V Glidden; Natrina L Johnson; Kurt Giles; Stephen J DeArmond; Stanley B Prusiner
Journal: Prion Date: 2012 Jan-Mar Impact factor: 3.931

5. In vitro amplification of prions from milk in the detection of subclinical infections.

Authors: Kevin C Gough; Claire A Baker; Maged Taema; Ben C Maddison
Journal: Prion Date: 2009-10-23 Impact factor: 3.931

Review 6. The Ecology of Prions.

Authors: Mark Zabel; Aimee Ortega
Journal: Microbiol Mol Biol Rev Date: 2017-05-31 Impact factor: 11.056

Effect of repeated oral infection of hamsters with scrapie.

1. Rapid prion neuroinvasion following tongue infection.

2. Identification of upregulated genes in scrapie-infected brain tissue.

3. Repeated challenge with prion disease: the risk of infection and impact on incubation period.

4. Salivary prions in sheep and deer.

5. In vitro amplification of prions from milk in the detection of subclinical infections.

Review 6. The Ecology of Prions.

7. Prions in skeletal muscle.

8. High incidence of scrapie induced by repeated injections of subinfectious prion doses.

9. Assessment of Chronic Wasting Disease Prion Shedding in Deer Saliva with Occupancy Modeling.

10. Widespread PrPSc accumulation in muscles of hamsters orally infected with scrapie.