Literature DB >> 9519403

Processivity of DNA polymerases: two mechanisms, one goal.

Z Kelman1, J Hurwitz, M O'Donnell.   

Abstract

Replicative DNA polymerases are highly processive enzymes that polymerize thousands of nucleotides without dissociating from the DNA template. The recently determined structure of the Escherichia coli bacteriophage T7 DNA polymerase suggests a unique mechanism that underlies processivity, and this mechanism may generalize to other replicative polymerases.

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Year:  1998        PMID： 9519403     DOI： 10.1016/s0969-2126(98)00014-8

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  9 in total

1.  Evidence against a simple tethering model for enhancement of herpes simplex virus DNA polymerase processivity by accessory protein UL42.

Authors:  Murari Chaudhuri; Deborah S Parris
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103

2.  A novel strategy to engineer DNA polymerases for enhanced processivity and improved performance in vitro.

Authors:  Yan Wang; Dennis E Prosen; Li Mei; John C Sullivan; Michael Finney; Peter B Vander Horn
Journal:  Nucleic Acids Res       Date:  2004-02-18       Impact factor: 16.971

Review 3.  Phosphorylation mechanism and structure of serine-arginine protein kinases.

Authors:  Gourisankar Ghosh; Joseph A Adams
Journal:  FEBS J       Date:  2011-01-12       Impact factor: 5.542

4.  Thioredoxin, the processivity factor, sequesters an exposed cysteine in the thumb domain of bacteriophage T7 DNA polymerase.

Authors:  Ngoc Q Tran; Seung-Joo Lee; Barak Akabayov; Donald E Johnson; Charles C Richardson
Journal:  J Biol Chem       Date:  2012-09-25       Impact factor: 5.157

5.  Streamlined, automated protocols for the production of milligram quantities of untagged recombinant human cyclophilin-A (hCypA) and untagged human proliferating cell nuclear antigen (hPCNA) using AKTAxpress.

Authors:  Cornelia Ludwig; Martin A Wear; Malcolm D Walkinshaw
Journal:  Protein Expr Purif       Date:  2009-12-06       Impact factor: 1.650

6.  Interactions of Escherichia coli thioredoxin, the processivity factor, with bacteriophage T7 DNA polymerase and helicase.

Authors:  Sharmistha Ghosh; Samir M Hamdan; Timothy E Cook; Charles C Richardson
Journal:  J Biol Chem       Date:  2008-08-30       Impact factor: 5.157

7.  Two Approaches to Enhance the Processivity and Salt Tolerance of Staphylococcus aureus DNA Polymerase.

Authors:  Bing Zhai; Joseph Chow; Qi Cheng
Journal:  Protein J       Date:  2019-04       Impact factor: 2.371

Review 8.  Plant Organellar DNA Polymerases Evolved Multifunctionality through the Acquisition of Novel Amino Acid Insertions.

Authors:  Antolín Peralta-Castro; Paola L García-Medel; Noe Baruch-Torres; Carlos H Trasviña-Arenas; Víctor Juarez-Quintero; Carlos M Morales-Vazquez; Luis G Brieba
Journal:  Genes (Basel)       Date:  2020-11-19       Impact factor: 4.096

9.  Alternative RNA degradation pathways by the exonuclease Pop2p from Saccharomyces cerevisiae.

Authors:  Xuan Ye; Armend Axhemi; Eckhard Jankowsky
Journal:  RNA       Date:  2021-01-06       Impact factor: 4.942
  9 in total

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