Literature DB >> 9519297

Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes.

C A Brautigam1, T A Steitz.   

Abstract

New levels in the understanding of DNA replication have been achieved from recent crystal structure determinations of several DNA polymerases and their substrate complexes. The structure of an alpha family DNA polymerase from bacteriophage RB69 shows some similarities, but also considerable differences in structure and organization from the pol I family DNA polymerases. Also, the functions of three polymerase domains and their conserved residues have been clarified by studying structures of pol I family DNA polymerases complexed to their substrates. These structures also confirm that an identical two-metal ion catalytic mechanism proposed previously is used by both the nonhomologous pol I and pol beta family DNA polymerases.

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Year:  1998        PMID： 9519297     DOI： 10.1016/s0959-440x(98)80010-9

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  115 in total

1.  Mapping of ATP binding regions in poly(A) polymerases by photoaffinity labeling and by mutational analysis identifies a domain conserved in many nucleotidyltransferases.

Authors:  G Martin; P Jenö; W Keller
Journal:  Protein Sci       Date:  1999-11       Impact factor: 6.725

2.  Directed evolution of polymerase function by compartmentalized self-replication.

Authors:  F J Ghadessy; J L Ong; P Holliger
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-27       Impact factor: 11.205

3.  Three telomerases with completely non-telomeric template replacements are catalytically active.

Authors:  T L Ware; H Wang; E H Blackburn
Journal:  EMBO J       Date:  2000-06-15       Impact factor: 11.598

4.  Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius.

Authors:  K P Hopfner; A Eichinger; R A Engh; F Laue; W Ankenbauer; R Huber; B Angerer
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

5.  X-ray crystallographic observation of "in-line" and "adjacent" conformations in a bulged self-cleaving RNA/DNA hybrid.

Authors:  V Tereshko; S T Wallace; N Usman; F E Wincott; M Egli
Journal:  RNA       Date:  2001-03       Impact factor: 4.942

6.  Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus.

Authors:  S Bressanelli; L Tomei; A Roussel; I Incitti; R L Vitale; M Mathieu; R De Francesco; F A Rey
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-09       Impact factor: 11.205

7.  Heat shock protein 90-independent activation of truncated hepadnavirus reverse transcriptase.

Authors:  Xingtai Wang; Xiaofeng Qian; Hwai-Chen Guo; Jianming Hu
Journal:  J Virol       Date:  2003-04       Impact factor: 5.103

8.  Function of the C-terminus of phi29 DNA polymerase in DNA and terminal protein binding.

Authors:  Verónica Truniger; José M Lázaro; Margarita Salas
Journal:  Nucleic Acids Res       Date:  2004-01-16       Impact factor: 16.971

9.  Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations.

Authors:  Sean J Johnson; Jeffrey S Taylor; Lorena S Beese
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-20       Impact factor: 11.205

10.  Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure.

Authors:  Mayuko Okabe; Kozo Tomita; Ryuichiro Ishitani; Ryohei Ishii; Nono Takeuchi; Fumio Arisaka; Osamu Nureki; Shigeyuki Yokoyama
Journal:  EMBO J       Date:  2003-11-03       Impact factor: 11.598
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