Endothelial-cell development: pressure-flow phenomena.

Scanning electron micrographs showed directional orientation and cytoplasmic changes in the seeded cells after 21 days of perfusion. From this evidence it is theorized that human fibroblasts, exposed to physiological pressures and flows, exhibit morphological characteristics similar to arterial endothelial cells. Conceivably, cells other than fibroblasts (i.e., multipotential cells) would show the same response to these pressure and flow conditions.