Literature DB >> 9518431

[Synthesis and antiherpes activity of acyclovir phosphoesters].

G A Galegov1, V M Shobukhov, N A Leont'eva, M V Ias'ko.   

Abstract

9-(Hydroxyethyloxymethyl)guanine (acyclovir) phosphite and fluorophosphate were synthesized by the reactions of acyclovir with phosphorus trichloride in triethyl phosphate and with fluorophosphoric acid in the presence of 2,4,6-triisopropylbenzenesulfonyl chloride, respectively, and characterized by the data of 1H and 31P NMR and mass spectra. These products selectively inhibit reproduction of the herpes simplex virus type 1 in the Vero cell culture, the phosphite being also substantially active against a herpes virus strain resistant to acyclovir.

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Year:  1997        PMID： 9518431

Source DB:  PubMed          Journal:  Bioorg Khim        ISSN： 0132-3423


  3 in total

1.  Antiherpetic activity of dimeric derivatives of netropsin.

Authors:  V L Andronova; S L Grokhovskii; A N Surovaya; G V Gurskii; G A Galegov
Journal:  Dokl Biochem Biophys       Date:  2001 Sep-Oct       Impact factor: 0.788

2.  DNA-binding and antiviral activity of bis-netropsins containing clusters of lysine residues in the N-terminal region.

Authors:  V L Andronova; S L Grokhovskii; A N Surovaya; G V Gurskii; G A Galegov
Journal:  Dokl Biochem Biophys       Date:  2004 Nov-Dec       Impact factor: 0.788

3.  The antiviral activity of the combinations of netropsin derivatives with modified nucleosides and phosphonoacetic acid as estimated in the model of herpesvirus type 1 in a vero cell culture.

Authors:  V L Andronova; S L Grokhovsky; A N Surovaya; G V Gursky; G A Galegov
Journal:  Dokl Biochem Biophys       Date:  2005 Jan-Feb       Impact factor: 0.788
  3 in total

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