Literature DB >> 9517929

In vitro antimalarial activity of a new organometallic analog, ferrocene-chloroquine.

O Domarle1, G Blampain, H Agnaniet, T Nzadiyabi, J Lebibi, J Brocard, L Maciejewski, C Biot, A J Georges, P Millet.   

Abstract

The in vitro activities of new organometallic chloroquine analogs, based on 4-amino-quinoleine compounds bound to a molecule of ferrocene, were evaluated against chloroquine-susceptible, chloroquine-intermediate, and chloroquine-resistant, culture-adapted Plasmodium falciparum lineages by a proliferation test. One of the ferrocene analogs totally restored the activity of chloroquine against chloroquine-resistant parasites. This compound, associated with tartaric acid for better solubility, was highly effective. The role of the ferrocene in reversing chloroquine resistance is discussed, as is its potential use for human therapy.

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Year:  1998        PMID： 9517929      PMCID： PMC105495     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  40 in total

1.  Antimalarial schizontocides: ferriprotoporphyrin IX interaction hypothesis.

Authors:  C D Fitch
Journal:  Parasitol Today       Date:  1986-12

2.  A protein on Plasmodium falciparum-infected erythrocytes functions as a transferrin receptor.

Authors:  M H Rodriguez; M Jungery
Journal:  Nature       Date:  1986 Nov 27-Dec 3       Impact factor: 49.962

3.  Aminoquinolines that circumvent resistance in Plasmodium falciparum in vitro.

Authors:  D De; F M Krogstad; F B Cogswell; D J Krogstad
Journal:  Am J Trop Med Hyg       Date:  1996-12       Impact factor: 2.345

4.  Toxicological evaluation of substituted dicyclopentadienyliron (ferrocene) compounds.

Authors:  H W Leung; D W Hallesy; L D Shott; F J Murray; D J Paustenbach
Journal:  Toxicol Lett       Date:  1987-09       Impact factor: 4.372

5.  A reappraisal of the effects of iron and desferrioxamine on the growth of Plasmodium falciparum 'in vitro': the unimportance of serum iron.

Authors:  T E Peto; J L Thompson
Journal:  Br J Haematol       Date:  1986-06       Impact factor: 6.998

6.  Simulation of kinetic data on the influx and efflux of chloroquine by erythrocytes infected with Plasmodium falciparum. Evidence for a drug-importer in chloroquine-sensitive strains.

Authors:  V Ferrari; D J Cutler
Journal:  Biochem Pharmacol       Date:  1991-12-11       Impact factor: 5.858

7.  4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum.

Authors:  R G Ridley; W Hofheinz; H Matile; C Jaquet; A Dorn; R Masciadri; S Jolidon; W F Richter; A Guenzi; M A Girometta; H Urwyler; W Huber; S Thaithong; W Peters
Journal:  Antimicrob Agents Chemother       Date:  1996-08       Impact factor: 5.191

8.  Reversal of chloroquine resistance in Plasmodium falciparum by verapamil.

Authors:  S K Martin; A M Oduola; W K Milhous
Journal:  Science       Date:  1987-02-20       Impact factor: 47.728

9.  A transferrin-independent iron uptake activity in Plasmodium falciparum-infected and uninfected erythrocytes.

Authors:  R Sanchez-Lopez; K Haldar
Journal:  Mol Biochem Parasitol       Date:  1992-10       Impact factor: 1.759

10.  Refeeding-malaria and hyperferraemia.

Authors:  M J Murray; N J Murray; A B Murray; M B Murray
Journal:  Lancet       Date:  1975-03-22       Impact factor: 79.321
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  16 in total

1.  Inhibitory activity of ferroquine, versus chloroquine, against western Kenya Plasmodium falciparum field isolates determined by a SYBR Green I in vitro assay.

Authors:  Fredrick L Eyase; Hoseah M Akala; Jacob D Johnson; Douglas S Walsh
Journal:  Am J Trop Med Hyg       Date:  2011-12       Impact factor: 2.345

2.  Synthesis and antimalarial activity of metal complexes of cross-bridged tetraazamacrocyclic ligands.

Authors:  Timothy J Hubin; Prince N-A Amoyaw; Kimberly D Roewe; Natalie C Simpson; Randall D Maples; TaRynn N Carder Freeman; Amy N Cain; Justin G Le; Stephen J Archibald; Shabana I Khan; Babu L Tekwani; M O Faruk Khan
Journal:  Bioorg Med Chem       Date:  2014-05-11       Impact factor: 3.641

3.  Design, Synthesis and Evaluation of Bifunctional Acridinine-Naphthalenediimide Redox-Active Conjugates as Antimalarials.

Authors:  Srikanta Dana; Sudhir Kumar Keshri; Jyoti Shukla; Kunwar Somesh Vikramdeo; Neelima Mondal; Pritam Mukhopadhyay; Suman Kumar Dhar
Journal:  ACS Omega       Date:  2016-09-01

4.  Pharmacokinetics of ferroquine, a novel 4-aminoquinoline, in asymptomatic carriers of Plasmodium falciparum infections.

Authors:  Christian Supan; Ghyslain Mombo-Ngoma; Matthias P Dal-Bianco; Carmen L Ospina Salazar; Saadou Issifou; Florent Mazuir; Aziz Filali-Ansary; Christophe Biot; Daniel Ter-Minassian; Michael Ramharter; Peter G Kremsner; Bertrand Lell
Journal:  Antimicrob Agents Chemother       Date:  2012-03-19       Impact factor: 5.191

5.  In vitro activity of ferroquine is independent of polymorphisms in transport protein genes implicated in quinoline resistance in Plasmodium falciparum.

Authors:  Maud Henry; Sébastien Briolant; Albin Fontaine; Joel Mosnier; Eric Baret; Rémy Amalvict; Thierry Fusaï; Laurent Fraisse; Christophe Rogier; Bruno Pradines
Journal:  Antimicrob Agents Chemother       Date:  2008-05-27       Impact factor: 5.191

6.  Phase I randomized dose-ascending placebo-controlled trials of ferroquine--a candidate anti-malarial drug--in adults with asymptomatic Plasmodium falciparum infection.

Authors:  Ghyslain Mombo-Ngoma; Christian Supan; Matthias P Dal-Bianco; Michel A Missinou; Pierre-Blaise Matsiegui; Carmen L Ospina Salazar; Saadou Issifou; Daniel Ter-Minassian; Michael Ramharter; Maryvonne Kombila; Peter G Kremsner; Bertrand Lell
Journal:  Malar J       Date:  2011-03-01       Impact factor: 2.979

7.  Structural modifications of quinoline-based antimalarial agents: Recent developments.

Authors:  Sandhya Bawa; Suresh Kumar; Sushma Drabu; Rajiv Kumar
Journal:  J Pharm Bioallied Sci       Date:  2010-04

Review 8.  Metallodrugs are unique: opportunities and challenges of discovery and development.

Authors:  Elizabeth J Anthony; Elizabeth M Bolitho; Hannah E Bridgewater; Oliver W L Carter; Jane M Donnelly; Cinzia Imberti; Edward C Lant; Frederik Lermyte; Russell J Needham; Marta Palau; Peter J Sadler; Huayun Shi; Fang-Xin Wang; Wen-Ying Zhang; Zijin Zhang
Journal:  Chem Sci       Date:  2020-11-12       Impact factor: 9.825

9.  Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure.

Authors:  Wassim Daher; Christophe Biot; Thierry Fandeur; Helene Jouin; Lydie Pelinski; Eric Viscogliosi; Laurent Fraisse; Bruno Pradines; Jacques Brocard; Jamal Khalife; Daniel Dive
Journal:  Malar J       Date:  2006-02-07       Impact factor: 2.979

10.  In vitro activity of ferroquine (SSR 97193) against Plasmodium falciparum isolates from the Thai-Burmese border.

Authors:  Marion Barends; Anchalee Jaidee; Nopparat Khaohirun; Pratap Singhasivanon; François Nosten
Journal:  Malar J       Date:  2007-06-27       Impact factor: 2.979
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