Literature DB >> 9514006

Fomitellic acids, triterpenoid inhibitors of eukaryotic DNA polymerases from a basidiomycete, Fomitella fraxinea.

N Tanaka1, A Kitamura, Y Mizushina, F Sugawara, K Sakaguchi.   

Abstract

Four new triterpenoid compounds, 1-4, were isolated from the mycelium of a basidiomycete, Fomitella fraxinea, and their structures determined by spectroscopic analyses. Compounds 1-5 inhibited calf DNA polymerase alpha and rat DNA polymerase beta, with respective minimum inhibitory concentration (MIC) ranges of 35-75 and 90-130 microM.

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Year:  1998        PMID： 9514006     DOI： 10.1021/np970127a

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

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Journal:  Life Sci       Date:  2015-09-01       Impact factor: 5.037

Review 2.  Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency.

Authors:  Julie K Horton; Samuel H Wilson
Journal:  DNA Repair (Amst)       Date:  2006-11-20

3.  Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase.

Authors:  Y Mizushina; A Iida; K Ohta; F Sugawara; K Sakaguchi
Journal:  Biochem J       Date:  2000-09-15       Impact factor: 3.857

4.  Inhibitory action of emulsified sulfoquinovosyl acylglycerol on mammalian DNA polymerases.

Authors:  Yoshiyuki Mizushina; Naoki Maeda; Miho Kawasaki; Hideki Ichikawa; Chikako Murakami; Masaharu Takemura; Xianai Xu; Fumio Sugawara; Yoshinobu Fukumori; Hiromi Yoshida; Kengo Sakaguchi
Journal:  Lipids       Date:  2003-10       Impact factor: 1.880

5.  The relationship between the molecular structure of natural acetogenins and their inhibitory activities which affect DNA polymerase, DNA topoisomerase and human cancer cell growth.

Authors:  Yuki Matsui; Toshifumi Takeuchi; Yuko Kumamoto-Yonezawa; Masaharu Takemura; Fumio Sugawara; Hiromi Yoshida; Yoshiyuki Mizushina
Journal:  Exp Ther Med       Date:  2010-01-01       Impact factor: 2.447

6.  Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs.

Authors:  Supriya Baikar; Nutan Malpathak
Journal:  Pharmacogn Rev       Date:  2010-01

Review 7.  DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair.

Authors:  Elisa Mentegari; Miroslava Kissova; Laura Bavagnoli; Giovanni Maga; Emmanuele Crespan
Journal:  Genes (Basel)       Date:  2016-08-31       Impact factor: 4.096

8.  Structure-activity relationship of a novel group of mammalian DNA polymerase inhibitors, synthetic sulfoquinovosylacylglycerols.

Authors:  S Hanashima; Y Mizushina; K Ohta; T Yamazaki; F Sugawara; K Sakaguchi
Journal:  Jpn J Cancer Res       Date:  2000-10

9.  Yellow pigments, fomitellanols A and B, and drimane sesquiterpenoids, cryptoporic acids P and Q, from Fomitella fraxinea and their inhibitory activity against COX and 5-LO.

Authors:  Kazuko Yoshikawa; Kazuaki Koso; Masumi Shimomura; Masami Tanaka; Hirofumi Yamamoto; Hiroshi Imagawa; Shigenobu Arihara; Toshihiro Hashimoto
Journal:  Molecules       Date:  2013-04-09       Impact factor: 4.411
  9 in total

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