| Literature DB >> 9514005 |
A A Gunatilaka1, V da S Bolzani, E Dagne, G A Hofmann, R K Johnson, F L McCabe, M R Mattern, D G Kingston.
Abstract
Bioactivity-directed fractionation of the MeCOEt extract of Trichilia emetica (Meliaceae) resulted in the isolation of the limonoids nymania 1 (1), drageana 4 (3), trichilin A (4), rohituka 3 (5), and Tr-B (7) and the novel seco-A protolimonoid 8. Of these, nymania 1 and Tr-B showed selective inhibitory activity toward DNA repair-deficient yeast mutants. The isolation, structure elucidation, 13C NMR spectral assignments, and biological activities of these compounds are reported.Entities:
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Year: 1998 PMID： 9514005 DOI： 10.1021/np9701687
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050