M Strober1, U Rao, M DeAntonio, E Liston, M State, L Amaya-Jackson, S Latz. 1. Department of Psychiatry & Biobehavioral Sciences, Neuropsychiatric Institute & Hospital, School of Medicine, University of California at Los Angeles 90024-1759, USA.
Abstract
BACKGROUND: This open, prospective study examined the effects of electroconvulsive therapy (ECT) in 10 adolescents with primary, endogenous, psychotic depression who were resistant to antidepressant pharmacotherapy. METHODS: Change in symptom severity from baseline was assessed weekly with Hamilton Depression Rating Scale (HDRS) ratings, and outcome was measured additionally at 1 month, and again at 1 year, post-ECT. RESULTS: All but 1 patient demonstrated dramatic improvement, with statistically significant decreases in mean HDRS score detected after the first week of treatment. All responders maintained the benefits of their treatment. CONCLUSIONS: The results provide evidence of the clinical effectiveness of ECT in adolescents with phenomenological characteristics shown to be predictive of ECT response in adults.
BACKGROUND: This open, prospective study examined the effects of electroconvulsive therapy (ECT) in 10 adolescents with primary, endogenous, psychotic depression who were resistant to antidepressant pharmacotherapy. METHODS: Change in symptom severity from baseline was assessed weekly with Hamilton Depression Rating Scale (HDRS) ratings, and outcome was measured additionally at 1 month, and again at 1 year, post-ECT. RESULTS: All but 1 patient demonstrated dramatic improvement, with statistically significant decreases in mean HDRS score detected after the first week of treatment. All responders maintained the benefits of their treatment. CONCLUSIONS: The results provide evidence of the clinical effectiveness of ECT in adolescents with phenomenological characteristics shown to be predictive of ECT response in adults.
Authors: Nádia Nr Lima; Vânia B Nascimento; Jorge Ac Peixoto; Marcial M Moreira; Modesto Lr Neto; José C Almeida; Carlos Ac Vasconcelos; Saulo A Teixeira; Jucier G Júnior; Francisco Tc Junior; Diego Dm Guimarães; Aline Q Brasil; Jesus S Cartaxo; Marco Akerman; Alberto Oa Reis Journal: Ann Gen Psychiatry Date: 2013-05-30 Impact factor: 3.455