Literature DB >> 9512375

Neurosteroids act on the GABA(A) receptor at sites on the N-terminal side of the middle of TM2.

C E Rick1, Q Ye, S E Finn, N L Harrison.   

Abstract

Two sets of chimeras between alphaxalone-sensitive GABA(A) receptor alpha2 or beta1 subunits and the alphaxalone-insensitive glycine receptor alpha1 subunit were constructed to determine the structural domains important for the modulatory actions of neuroactive steroids. These data suggest that the site of action for neurosteroids on GABA(A) receptors is not the same as that for volatile anesthetics and ethanol, but is on the N-terminal side of the middle of TM2.

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Year:  1998        PMID： 9512375     DOI： 10.1097/00001756-199802160-00004

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  11 in total

Review 1.  General anaesthetic actions on ligand-gated ion channels.

Authors:  M D Krasowski; N L Harrison
Journal:  Cell Mol Life Sci       Date:  1999-08-15       Impact factor: 9.261

2.  Neurosteroid modulation of GABA IPSCs is phosphorylation dependent.

Authors:  A Fáncsik; D M Linn; J G Tasker
Journal:  J Neurosci       Date:  2000-05-01       Impact factor: 6.167

3.  Oxytocin regulates neurosteroid modulation of GABA(A) receptors in supraoptic nucleus around parturition.

Authors:  Jan-Jurjen Koksma; Ronald E van Kesteren; Thomas W Rosahl; Ruud Zwart; August B Smit; Hartmut Lüddens; Arjen B Brussaard
Journal:  J Neurosci       Date:  2003-02-01       Impact factor: 6.167

Review 4.  Modulating inhibitory ligand-gated ion channels.

Authors:  Michael Cascio
Journal:  AAPS J       Date:  2006-05-26       Impact factor: 4.009

5.  Complementary regulation of anaesthetic activation of human (alpha6beta3gamma2L) and Drosophila (RDL) GABA receptors by a single amino acid residue.

Authors:  M Pistis; D Belelli; K McGurk; J A Peters; J J Lambert
Journal:  J Physiol       Date:  1999-02-15       Impact factor: 5.182

6.  Specific binding sites for alcohols and anesthetics on ligand-gated ion channels.

Authors:  M P Mascia; J R Trudell; R A Harris
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-01       Impact factor: 11.205

7.  Changes in properties and neurosteroid regulation of GABAergic synapses in the supraoptic nucleus during the mammalian female reproductive cycle.

Authors:  A B Brussaard; P Devay; J L Leyting-Vermeulen; K S Kits
Journal:  J Physiol       Date:  1999-04-15       Impact factor: 5.182

8.  The C terminus of the human nicotinic alpha4beta2 receptor forms a binding site required for potentiation by an estrogenic steroid.

Authors:  K Paradiso; J Zhang; J H Steinbach
Journal:  J Neurosci       Date:  2001-09-01       Impact factor: 6.167

9.  A mutant residue in the third transmembrane region of the GABA(A) alpha1 subunit causes increased agonistic neurosteroid responses.

Authors:  Daniel B Williams
Journal:  Neurochem Int       Date:  2011-03-21       Impact factor: 3.921

10.  Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids.

Authors:  Gustav Akk; Douglas F Covey; Alex S Evers; Steven Mennerick; Charles F Zorumski; Joe Henry Steinbach
Journal:  Curr Neuropharmacol       Date:  2010-03       Impact factor: 7.363
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