Literature DB >> 9511904

1,4-Dihydroxynonene mercapturic acid, the major end metabolite of exogenous 4-hydroxy-2-nonenal, is a physiological component of rat and human urine.

J Alary1, L Debrauwer, Y Fernandez, J P Cravedi, D Rao, G Bories.   

Abstract

In the present study 1,4-dihydroxynonene mercapturic acid (DHN-MA), previously shown to be the major urinary metabolite of 4-hydroxy-2-nonenal (HNE) administered to the rat, was characterized and determined to be a normal constituent of rat and human urine. DHN-MA was excreted as a mixture of at least two stereoisomers as determined by ion trap LC-MS/MS/MS after solid-phase extraction and HPLC purification. The 24-h urinary excretion of this compound was about 10 ng and 5 microg for rat and human, respectively. This end metabolite of the lipid peroxidation product HNE could represent a specific and noninvasive biomarker.

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Year:  1998        PMID： 9511904     DOI： 10.1021/tx970139w

Source DB:  PubMed          Journal:  Chem Res Toxicol        ISSN： 0893-228X            Impact factor:   3.739


  15 in total

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2.  LC-MS/MS quantitation of mercapturic acid conjugates of lipid peroxidation products as markers of oxidative stress.

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7.  Synthesis of 9,9,9-trideutero-1,4-dihydroxynonane mercapturic acid (d3-DHN-MA), a useful internal standard for DHN-MA urinalysis.

Authors:  B Chantegrel; C Deshayes; A Doutheau; J P Steghens
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Review 8.  Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease.

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9.  The stereochemical course of 4-hydroxy-2-nonenal metabolism by glutathione S-transferases.

Authors:  Larissa M Balogh; Arthur G Roberts; Laura M Shireman; Robert J Greene; William M Atkins
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10.  Mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites are in vivo markers of oxidative stress.

Authors:  Heather C Kuiper; Cristobal L Miranda; John D Sowell; Jan F Stevens
Journal:  J Biol Chem       Date:  2008-04-27       Impact factor: 5.157
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