| Literature DB >> 951014 |
A J Donker, L Arisz, J R Brentjens, G K van der Hem, H J Hollemans.
Abstract
125Iothalamate and 131I-hippuran clearances, sodium excretion and plasma renin activity (PRA) before and during indomethacin administration in an oral dose of 3 x 50 mg/day were studied in volunteers with a normal or reduced kidney function, as well on non-sodium-restricted as on sodium-restricted diet. Indomethacin induced a temporary sodium and water retention and a decrease in glomerular filtration rate. It also lowered PRA. The latter phenomenon did not depend on sodium retention and was present within 2 h after an oral dose of 50 mg. The results may be explained by indomethacin-induced inhibition of prostaglandin synthesis.Entities:
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Year: 1976 PMID： 951014 DOI： 10.1159/000180733
Source DB: PubMed Journal: Nephron ISSN： 1660-8151 Impact factor: 2.847