Literature DB >> 9509996

Characterization of the 5' region of the rat brain glycine transporter GLYT2 gene: identification of a novel isoform.

J Ponce1, I Poyatos, C Aragón, C Giménez, F Zafra.   

Abstract

We have identified two alternative 5' ends for the GLYT2 glycine transporter in rat brain DNA by using rapid amplification of cDNA ends (RACE) analysis. Study of the genomic DNA revealed that the isoform diversity is generated by alternative use of exons 1a or 1b, respectively. Upon translation, the mRNA corresponding to the novel isoform GLYT2b would yield a protein five amino acids longer than the previously characterized isoform GLYT2a. Both forms display similar regional distribution and kinetics characteristics. However, whereas GLYT2a is able to actively accumulate glycine into transfected COS cells, GLYT2b seems only to exchange (or release) glycine.

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Year:  1998        PMID： 9509996     DOI： 10.1016/s0304-3940(98)00037-8

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  12 in total

1.  Differential effects of ethanol on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters.

Authors:  E Núñez; B López-Corcuera; R Martínez-Maza; C Aragón
Journal:  Br J Pharmacol       Date:  2000-02       Impact factor: 8.739

2.  Calpain sensitive regions in the N-terminal cytoplasmic domains of glycine transporters GlyT1A and GlyT1B.

Authors:  Martina Baliova; Frantisek Jursky
Journal:  Neurochem Res       Date:  2005-09       Impact factor: 3.996

Review 3.  Molecular targets and mechanisms for ethanol action in glycine receptors.

Authors:  Daya I Perkins; James R Trudell; Daniel K Crawford; Ronald L Alkana; Daryl L Davies
Journal:  Pharmacol Ther       Date:  2010-04-23       Impact factor: 12.310

4.  N[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport.

Authors:  K R Aubrey; R J Vandenberg
Journal:  Br J Pharmacol       Date:  2001-12       Impact factor: 8.739

5.  The role of glycineB binding site and glycine transporter (GlyT1) in the regulation of [3H]GABA and [3H]glycine release in the rat brain.

Authors:  L G Harsing; S Solyom; C Salamon
Journal:  Neurochem Res       Date:  2001-09       Impact factor: 3.996

6.  Differential effects of the tricyclic antidepressant amoxapine on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters.

Authors:  E Núñez; B López-Corcuera; J Vázquez; C Giménez; C Aragón
Journal:  Br J Pharmacol       Date:  2000-01       Impact factor: 8.739

7.  The glycinergic system in human startle disease: a genetic screening approach.

Authors:  Jeff S Davies; Seo-Kyung Chung; Rhys H Thomas; Angela Robinson; Carrie L Hammond; Jonathan G L Mullins; Eloisa Carta; Brian R Pearce; Kirsten Harvey; Robert J Harvey; Mark I Rees
Journal:  Front Mol Neurosci       Date:  2010-03-23       Impact factor: 5.639

8.  The specification of glycinergic neurons and the role of glycinergic transmission in development.

Authors:  Alexander V Chalphin; Margaret S Saha
Journal:  Front Mol Neurosci       Date:  2010-04-22       Impact factor: 5.639

9.  Pharmacological properties of glycine transport in the frog retina.

Authors:  Jorge A Pérez-León; Estuardo López-Vera; Rocío Salceda
Journal:  Neurochem Res       Date:  2004-01       Impact factor: 3.996

10.  Calcium dependent interaction of calmodulin with the GlyT1 C-terminus.

Authors:  Andrea Mihalikova; Martina Baliova; Frantisek Jursky
Journal:  Neurochem Res       Date:  2014-08-29       Impact factor: 3.996
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