Literature DB >> 9507951

Transferrin C2, metal binding and Alzheimer's disease.

G F Van Landeghem1, C Sikström, L E Beckman, R Adolfsson, L Beckman.   

Abstract

Significant associations between the transferrin (TF) variant C2 and a number of disorders suspected to be caused by oxygen free radicals have been reported. Thus an increased frequency of the TFC2 variant has been found in patients with Alzheimer's disease (AD), and it has been hypothesized that AD is caused by free radical damage due to defective binding of iron and aluminium by TFC2. In a study of 64 patients with AD from northern Sweden we were able to confirm the association between TFC2 and AD, but there were no significant differences between TFC2 and other TF variants with respect to the binding of iron and aluminium.

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Year:  1998        PMID： 9507951     DOI： 10.1097/00001756-199801260-00001

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  12 in total

1.  Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease.

Authors:  J S K Kauwe; S Bertelsen; K Mayo; C Cruchaga; R Abraham; P Hollingworth; D Harold; M J Owen; J Williams; S Lovestone; J C Morris; A M Goate
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2010-06-05       Impact factor: 3.568

2.  Iron genes, iron load and risk of Alzheimer's disease.

Authors:  D J Lehmann; M Worwood; R Ellis; V L J Wimhurst; A T Merryweather-Clarke; D R Warden; A D Smith; K J H Robson
Journal:  J Med Genet       Date:  2006-10       Impact factor: 6.318

3.  Glycosylation of transferrin in Alzheimer's disease and alcohol-induced dementia.

Authors:  S J van Rensburg; P A Berman; F C Potocnik; J J Taljaard
Journal:  Metab Brain Dis       Date:  2000-12       Impact factor: 3.584

4.  Correlation of aluminum and manganese concentration in scalp hair samples of patients having neurological disorders.

Authors:  Mariam Shahzadi Arain; Hassan Imran Afridi; Tasneem Gul Kazi; Farah Naz Talpur; Mohammad Balal Arain; Atif Kazi; Salma Aslam Arain; Jamshed Ali
Journal:  Environ Monit Assess       Date:  2015-01-25       Impact factor: 2.513

Review 5.  Iron in chronic brain disorders: imaging and neurotherapeutic implications.

Authors:  James Stankiewicz; S Scott Panter; Mohit Neema; Ashish Arora; Courtney E Batt; Rohit Bakshi
Journal:  Neurotherapeutics       Date:  2007-07       Impact factor: 7.620

Review 6.  Neuroimaging, nutrition, and iron-related genes.

Authors:  Neda Jahanshad; Priya Rajagopalan; Paul M Thompson
Journal:  Cell Mol Life Sci       Date:  2013-07-02       Impact factor: 9.261

7.  Effect modification by transferrin C2 polymorphism on lead exposure, hemoglobin levels, and IQ.

Authors:  Ananya Roy; Adrienne S Ettinger; Howard Hu; David Bellinger; Joel Schwartz; Rama Modali; Robert O Wright; Kavitha Palaniappan; Kalpana Balakrishnan
Journal:  Neurotoxicology       Date:  2013-05-31       Impact factor: 4.294

8.  Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease.

Authors:  K J H Robson; D J Lehmann; V L C Wimhurst; K J Livesey; M Combrinck; A T Merryweather-Clarke; D R Warden; A D Smith
Journal:  J Med Genet       Date:  2004-04       Impact factor: 6.318

9.  5- and 6-glycosylation of transferrin in patients with Alzheimer's disease.

Authors:  Susan J van Rensburg; Peter Berman; Felix Potocnik; Pam MacGregor; Dinie Hon; Nico de Villiers
Journal:  Metab Brain Dis       Date:  2004-06       Impact factor: 3.584

10.  Cellular and biochemical actions of melatonin which protect against free radicals: role in neurodegenerative disorders.

Authors:  Genaro G Ortiz; Gloria A Benítez-King; Sergio A Rosales-Corral; Fermín P Pacheco-Moisés; Irma E Velázquez-Brizuela
Journal:  Curr Neuropharmacol       Date:  2008-09       Impact factor: 7.363
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