Literature DB >> 9507945

Cultured rat sensory neurones express functional tachykinin receptor subtypes 1, 2 and 3.

C Brechenmacher1, Y Larmet, P Feltz, J L Rodeau.   

Abstract

The neuropeptide substance P (SP) is known to play a key role in peripheral nociceptive processes. We investigated the in vitro pharmacological characteristics of functional tachykinin receptors expressed in dorsal root ganglia (DRG) sensory neurones by analysing intracellular free calcium concentration changes induced after stimulation by SP or specific tachykinin agonists. We observed that about 37% of the tested neurones were responsive to either SP or an NK1-, NK2- or NK3-specific agonist. Tachykinin-responsive neurones had a small soma diameter (<20 microm) and were sensitive to capsaicin. These results suggest the presence of NK1, NK2 and NK3 receptors in noxious sensory neurones.

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Year:  1998        PMID： 9507945     DOI： 10.1016/s0304-3940(98)00045-7

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  9 in total

1.  Neurokinins enhance excitability in capsaicin-responsive DRG neurons.

Authors:  Adrian Sculptoreanu; William C de Groat
Journal:  Exp Neurol       Date:  2007-02-14       Impact factor: 5.330

2.  Prostaglandin E2 increases the expression of the neurokinin1 receptor in adult sensory neurones in culture: a novel role of prostaglandins.

Authors:  Gisela Segond von Banchet; Anita Scholze; Hans-Georg Schaible
Journal:  Br J Pharmacol       Date:  2003-06       Impact factor: 8.739

3.  Neurokinins inhibit low threshold inactivating K+ currents in capsaicin responsive DRG neurons.

Authors:  Adrian Sculptoreanu; Debra E Artim; William C de Groat
Journal:  Exp Neurol       Date:  2009-07-23       Impact factor: 5.330

4.  Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats.

Authors:  Adrian Sculptoreanu; F Aura Kullmann; William C de Groat
Journal:  Eur J Neurosci       Date:  2008-06       Impact factor: 3.386

Review 5.  Tachykinin NK2 receptor antagonists for the treatment of irritable bowel syndrome.

Authors:  Alessandro Lecci; Angela Capriati; Carlo Alberto Maggi
Journal:  Br J Pharmacol       Date:  2004-03-22       Impact factor: 8.739

6.  Monoarticular antigen-induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats.

Authors:  G S von Banchet; P K Petrow; R Bräuer; H G Schaible
Journal:  Arthritis Res       Date:  2000-08-03

7.  Resolvin E1 Inhibits Substance P-Induced Potentiation of TRPV1 in Primary Sensory Neurons.

Authors:  Youn Yi Jo; Ji Yeon Lee; Chul-Kyu Park
Journal:  Mediators Inflamm       Date:  2016-09-25       Impact factor: 4.711

8.  Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons.

Authors:  John E Linley; Lezanne Ooi; Louisa Pettinger; Hannah Kirton; John P Boyle; Chris Peers; Nikita Gamper
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-14       Impact factor: 11.205

9.  Activation of the neurokinin-1 receptor by substance P triggers the release of substance P from cultured adult rat dorsal root ganglion neurons.

Authors:  He-Bin Tang; Yu-Sang Li; Koji Arihiro; Yoshihiro Nakata
Journal:  Mol Pain       Date:  2007-12-25       Impact factor: 3.395
  9 in total

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