Literature DB >> 9507194

Decreased soluble interleukin-6 receptor in cerebrospinal fluid of patients with Alzheimer's disease.

H Hampel1, T Sunderland, H U Kötter, C Schneider, S J Teipel, F Padberg, R Dukoff, J Levy, H J Möller.   

Abstract

The function of the cytokine interleukin-6 (IL-6) is augmented by soluble IL-6 receptors (sIL-6R). We investigated cerebrospinal fluid sIL-6R concentrations in patients with Alzheimer's disease (AD) compared to age-matched healthy subjects and individuals with at least one first degree relative with AD. We found a statistically significant decrease in sIL-6R levels in the AD group compared to controls. Complete analysis of the IL-6R complex seems crucial to better understand the impact of IL-6 in AD pathophysiology.

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Year:  1998        PMID： 9507194     DOI： 10.1016/s0006-8993(97)01355-3

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  10 in total

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  10 in total

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