Literature DB >> 950654

Synthesis of 1- and 2-substituted indazoles as anthelmintic agents.

W D Kingsbury, R J Gyurik, V J Theodorides, R C Parish, G Gallagher.   

Abstract

Selective synthesis of 1- and 2-acyl-, alkoxycarbonyl-, and carbamoylindazoles are described. Spectroscopic data which were the basis for structural assignments are presented. These compounds, particularly methyl 2H-indazole-2-carboxylate and N-heptyl-N-methyl-2H-indazole-2-carboxamide, lack the spectrum of anthelmintic activity of the benzimidazole and benzotriazole anthelmintics to which they are structurally related.

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Year:  1976        PMID: 950654     DOI: 10.1021/jm00228a021

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


  1 in total

1.  Synthesis and structural characterization of 1- and 2-substituted indazoles: ester and carboxylic acid derivatives.

Authors:  Fátima C Teixeira; Hélène Ramos; Inês F Antunes; M João M Curto; M Teresa Duarte; Isabel Bento
Journal:  Molecules       Date:  2006-11-14       Impact factor: 4.411

  1 in total

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