| Literature DB >> 950644 |
B F Cain, G J Atwell, W A Denny.
Abstract
9-Anilino-10-methylacridinium salts result from reaction of substituted anilines and 9-chloro-10-methylacridinium salts in turn prepared from the 10-methyl-9(10H)-acridones and SOCl2 or POCl3. Antileukemic (L1210) activities of the quaternary salts were uniformly depressed compared to their unquaternized counterparts. If drug-solvent partition properties (log P) of the cations were considered, log P-activity relationships were similar for both base and quaternary salt series. Substituent effects on antitumor activity were similar in both series.Entities:
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Year: 1976 PMID： 950644 DOI： 10.1021/jm00228a007
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446