| Literature DB >> 9503473 |
T Nakajima1, K Hamanaka, T Fukuda, T Oyama, K Kashiwabara, T Sano.
Abstract
During immunohistochemical studies of cyclooxygenase-2 (COX-2) on human colon cancers, many strong COX-2-immunoreactive cells scattered in the bottom of the crypt of normal colon mucosa were unexpectedly noticed. COX-2-immunoreactive cells were morphologically very similar to neuroendocrine cells and were confirmed immunohistochemically to be positive for chromogranin A or serotonin. Moreover, COX-2-immunoreactive neuroendocrine cells were observed not only in the large intestine, but also in the stomach, duodenum and small intestine. The role of COX-2 expression in neuroendocrine cells of the human alimentary tract was speculated.Entities:
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Year: 1997 PMID： 9503473 DOI： 10.1111/j.1440-1827.1997.tb03723.x
Source DB: PubMed Journal: Pathol Int ISSN： 1320-5463 Impact factor: 2.534