Literature DB >> 950019

[Reversal of the pressor effect of PGF2alpha in the rat (author's transl)].

J Damas.   

Abstract

In normal rats, prostaglandin F2alpha is a potent vasoconstrictor. The corresponding systemic hypertension is progressively attenuated by tachyphylaxis, revealing a longlasting fall of blood pressure. Tachyphylaxis is accelerated by previous injection of arachidonic acid and bradyskinin. The vasodepressive activity of PGF2alpha is inhibited by indomethacin.

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Year:  1976        PMID： 950019     DOI： 10.1007/bf01919855

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  Actions of prostaglandins on the arterial system of the sheep: some structure-activity relationships.

Authors:  R L Jones
Journal:  Br J Pharmacol       Date:  1975-03       Impact factor: 8.739

2.  Correlation between inhibition by anti-inflammatory substances, of arachidonic acid-induced hypotension and of prostaglandin biosynthesis in vitro.

Authors:  J Damas; C Deby
Journal:  Biochem Pharmacol       Date:  1976-04-15       Impact factor: 5.858

3.  Cardiovascular responses to prostaglandin F2 alpha in spontaneously hypertensive rats.

Authors:  E Ellis; P Hutchins
Journal:  Prostaglandins       Date:  1974-08-25

4.  Proceedings: The reduction of prostaglandin E2 to prostaglandin F2alpha by various animal tissues.

Authors:  C N Hensby; E W Horton
Journal:  Br J Pharmacol       Date:  1974-09       Impact factor: 8.739

5.  Studies on the mechanism of the hypertensive effect of prostaglandin F2-alpha.

Authors:  D W Ducharme; J R Weeks; R G Montgomery
Journal:  J Pharmacol Exp Ther       Date:  1968-03       Impact factor: 4.030

6.  [Prostaglandin liberation by bradykinin in the rat].

Authors:  J Damas; C Deby
Journal:  C R Seances Soc Biol Fil       Date:  1974

7.  Evidence for the presence of a prostaglandin E 2 -9-keto reductase in rat organs.

Authors:  C A Leslie; L Levine
Journal:  Biochem Biophys Res Commun       Date:  1973-06-08       Impact factor: 3.575

8.  Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

Authors:  J R Vane
Journal:  Nat New Biol       Date:  1971-06-23

9.  [Proceedings: Influence of tryptophan on the hypotensive effect of arachidonic acid].

Authors:  C Deby; J Damas
Journal:  Arch Int Physiol Biochim       Date:  1974-10

10.  Inhibitors of prostaglandin catabolism. I. Differential sensitivity of 9-PGDH, 13-PGR and 15-PGDH to low concentrations of indomethacin.

Authors:  C Pace-Asciak; S Cole
Journal:  Experientia       Date:  1975-02-15
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