Literature DB >> 9498678

High-performance liquid chromatographic determination of ritonavir in human plasma, cerebrospinal fluid and saliva.

R M Hoetelmans1, M van Essenberg, M Profijt, P L Meenhorst, J W Mulder, J H Beijnen.   

Abstract

A simple, ion-pair high-performance liquid chromatographic method has been developed and validated for the quantitative determination of the HIV protease inhibitor ritonavir in human plasma, cerebrospinal fluid and saliva. Sample pretreatment consisted of precipitation of proteins with acetonitrile prior to high-performance liquid chromatography with ultraviolet detection at 239 nm. The method has been validated over the range of 50 ng/ml to 50 microg/ml with use of 100-microl volumes of sample. The currently described assay has been used successfully for the analysis of ritonavir in plasma, cerebrospinal fluid and saliva in HIV-1 infected patients.

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Year:  1998        PMID： 9498678     DOI： 10.1016/s0378-4347(97)00500-8

Source DB:  PubMed          Journal:  J Chromatogr B Biomed Sci Appl        ISSN： 1387-2273


  6 in total

1.  The effect of fluconazole on ritonavir and saquinavir pharmacokinetics in HIV-1-infected individuals.

Authors:  C H Koks; K M Crommentuyn; R M Hoetelmans; D M Burger; P P Koopmans; R A Mathôt; J W Mulder; P L Meenhorst; J H Beijnen
Journal:  Br J Clin Pharmacol       Date:  2001-06       Impact factor: 4.335

2.  Pharmacokinetics of ritonavir and delavirdine in human immunodeficiency virus-infected patients.

Authors:  Mark J Shelton; Ross G Hewitt; John Adams; Andrew Della-Coletta; Steven Cox; Gene D Morse
Journal:  Antimicrob Agents Chemother       Date:  2003-05       Impact factor: 5.191

3.  The antiretroviral protease inhibitor ritonavir accelerates glutathione export from cultured primary astrocytes.

Authors:  Christian Arend; Maria Brandmann; Ralf Dringen
Journal:  Neurochem Res       Date:  2013-01-23       Impact factor: 3.996

Review 4.  Antiretroviral bioanalysis methods of tissues and body biofluids.

Authors:  Robin DiFrancesco; Getrude Maduke; Rutva Patel; Charlene R Taylor; Gene D Morse
Journal:  Bioanalysis       Date:  2013-02       Impact factor: 2.681

5.  Simple, Rapid and Validated LC Determination of Lopinavir in Rat Plasma and its Application in Pharmacokinetic Studies.

Authors:  Rahul Vats; Aditya Narasimha Murthy; Punna Rao Ravi
Journal:  Sci Pharm       Date:  2011-09-17

6.  Validation of simultaneous quantitative method of HIV protease inhibitors atazanavir, darunavir and ritonavir in human plasma by UPLC-MS/MS.

Authors:  Tulsidas Mishra; Pranav S Shrivastav
Journal:  ScientificWorldJournal       Date:  2014-01-23
  6 in total

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