OBJECTIVE: To investigate erythropoietin (EPO) production and the erythropoietic potency of recombinant human EPO in the multiple organ dysfunction syndrome. DESIGN: Randomized, prospective, controlled clinical trial. MATERIALS AND METHODS: Patients received either 600 IU/kg intravenous EPO three times weekly (n = 9) or saline (control, n = 10). MEASUREMENTS: EPO levels, circulating soluble receptors for tumor necrosis factor and interleukin-2, levels of interleukin-6 and intercellular adhesion molecule, and early peripheral blood cell progenitors. RESULTS:EPO production in the control group remained low. Pharmacologic EPO blood levels were associated with increased reticulocyte counts compared with both controls (p < 0.04) and baseline (p < 0.006). Increased levels of soluble receptors for tumor necrosis factor in the treatment group compared with the controls did not prevent this effect. Interleukin 6 inhibited reticulocyte production. CONCLUSION: Despite increased cytokine levels, pharmacologic EPO blood levels were associated with increased reticulocyte counts in patients with multiple organ dysfunction syndrome.
RCT Entities:
OBJECTIVE: To investigate erythropoietin (EPO) production and the erythropoietic potency of recombinant humanEPO in the multiple organ dysfunction syndrome. DESIGN: Randomized, prospective, controlled clinical trial. MATERIALS AND METHODS:Patients received either 600 IU/kg intravenous EPO three times weekly (n = 9) or saline (control, n = 10). MEASUREMENTS: EPO levels, circulating soluble receptors for tumor necrosis factor and interleukin-2, levels of interleukin-6 and intercellular adhesion molecule, and early peripheral blood cell progenitors. RESULTS:EPO production in the control group remained low. Pharmacologic EPO blood levels were associated with increased reticulocyte counts compared with both controls (p < 0.04) and baseline (p < 0.006). Increased levels of soluble receptors for tumor necrosis factor in the treatment group compared with the controls did not prevent this effect. Interleukin 6 inhibited reticulocyte production. CONCLUSION: Despite increased cytokine levels, pharmacologic EPO blood levels were associated with increased reticulocyte counts in patients with multiple organ dysfunction syndrome.
Authors: J Jason; L K Archibald; O C Nwanyanwu; M Bell; R J Jensen; E Gunter; I Buchanan; J Larned; P N Kazembe; H Dobbie; W R Jarvis Journal: Clin Exp Immunol Date: 2001-12 Impact factor: 4.330
Authors: Bita Mesgarpour; Benedikt H Heidinger; Michael Schwameis; Calvin Kienbacher; Cathal Walsh; Susanne Schmitz; Harald Herkner Journal: Intensive Care Med Date: 2013-08-09 Impact factor: 17.440