Literature DB >> 9498053

Myelin splitting, Schwann cell injury and demyelination in feline diabetic neuropathy.

A P Mizisin1, G D Shelton, S Wagner, C Rusbridge, H C Powell.   

Abstract

Nerve biopsy samples from two cats with spontaneously occurring diabetes were examined. The predominant nerve fiber abnormalities observed were restricted to the myelin sheath and Schwann cell. Reactive, degenerative and proliferative Schwann cell changes were evident but the most striking abnormality encountered was splitting and ballooning of the myelin sheath. These observations highlight the significance of Schwann cell injury in the pathogenesis of diabetic neuropathy.

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Year:  1998        PMID: 9498053     DOI: 10.1007/s004010050783

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN: 0001-6322            Impact factor:   17.088


  16 in total

1.  Taurine reduces nitrosative stress and nitric oxide synthase expression in high glucose-exposed human Schwann cells.

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2.  Neurotrophic modulation of myelinated cutaneous innervation and mechanical sensory loss in diabetic mice.

Authors:  J A Christianson; J M Ryals; M S Johnson; R T Dobrowsky; D E Wright
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3.  Bone Marrow-Derived Mesenchymal Stem Cells Improve Diabetic Neuropathy by Direct Modulation of Both Angiogenesis and Myelination in Peripheral Nerves.

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4.  Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy.

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Review 6.  Future treatments for diabetic neuropathy: clues from experimental neuropathy.

Authors:  Nigel A Calcutt
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7.  Endoneurial microvascular pathology in feline diabetic neuropathy.

Authors:  Jeannelyn S Estrella; Richard N Nelson; B K Sturges; Karen M Vernau; D Collette Williams; Richard A LeCouteur; G Diane Shelton; Andrew P Mizisin
Journal:  Microvasc Res       Date:  2007-12-23       Impact factor: 3.514

8.  Hyperglycemia and downregulation of caveolin-1 enhance neuregulin-induced demyelination.

Authors:  Cuijuan Yu; Shefali Rouen; Rick T Dobrowsky
Journal:  Glia       Date:  2008-06       Impact factor: 7.452

9.  The Effect of Co-administration of 4-Methylcatechol and Progesterone on Sciatic Nerve Function and Neurohistological Alterations in Streptozotocin-Induced Diabetic Neuropathy in Rats.

Authors:  Hamidreza Sameni; Marzieh Panahi
Journal:  Cell J       Date:  2011-04-21       Impact factor: 2.479

10.  High energy diets-induced metabolic and prediabetic painful polyneuropathy in rats.

Authors:  Fang Xie; Han Fu; Jun-Feng Hou; Kai Jiao; Michael Costigan; Jun Chen
Journal:  PLoS One       Date:  2013-02-25       Impact factor: 3.240

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