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Literature DB >> 9497905

Mouse glycine N-methyltransferase is sexually dimorphic and regulated by growth hormone.

Abstract

The secretion pattern of putuitary growth hormone (GH) in rodents is sexually dimorphic and regulates the expression of some hepatic genes. We report cloning of mouse glycine N-methyltransferase (GNMT) cDNA. The mouse GNMT mRNA is expressed at much lower levels in male than in female livers. Hypophysectomy in male mice resulted in as a high level of the expression as in female mice. Treatment with GH of hypophysectomized male mice twice a day for 5 days decreased the expression. These results indicate that the sex difference of the mouse GNMT expression is regulated by GH secretion patterns.

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Year: 1997 PMID： 9497905 DOI： 10.1055/s-2007-978982

Source DB: PubMed Journal: Horm Metab Res ISSN： 0018-5043 Impact factor: 2.936

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Cited

14 in total

1. Expression of DNA methyltransferases is influenced by growth hormone in the long-living Ames dwarf mouse in vivo and in vitro.

Authors: Vanessa L Armstrong; Sharlene Rakoczy; Lalida Rojanathammanee; Holly M Brown-Borg
Journal: J Gerontol A Biol Sci Med Sci Date: 2013-11-07 Impact factor: 6.053

Mouse glycine N-methyltransferase is sexually dimorphic and regulated by growth hormone.

1. Expression of DNA methyltransferases is influenced by growth hormone in the long-living Ames dwarf mouse in vivo and in vitro.

2. Associations between S-adenosylmethionine, S-adenosylhomocysteine, and colorectal adenoma risk are modified by sex.

3. A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme.

4. Metabolic adaptations to short-term every-other-day feeding in long-living Ames dwarf mice.

5. Candidate genes for panhypopituitarism identified by gene expression profiling.

6. Metabolic adaptation of short-living growth hormone transgenic mice to methionine restriction and supplementation.

7. Long-living growth hormone receptor knockout mice: potential mechanisms of altered stress resistance.

8. Sulfur-based redox alterations in long-lived Snell dwarf mice.

Review 9. Methionine flux to transsulfuration is enhanced in the long living Ames dwarf mouse.

10. Identification of phosphorylation sites in glycine N-methyltransferase from rat liver.