Literature DB >> 9497292

Hyperinnervation of neuromuscular junctions caused by GDNF overexpression in muscle.

Q T Nguyen1, A S Parsadanian, W D Snider, J W Lichtman.   

Abstract

Overexpression of glial cell line-derived neurotrophic factor (GDNF) by muscle greatly increased the number of motor axons innervating neuromuscular junctions in neonatal mice. The extent of hyperinnervation correlated with the amount of GDNF expressed in four transgenic lines. Overexpression of GDNF by glia and overexpression of neurotrophin-3 and neurotrophin-4 in muscle did not cause hyperinnervation. Thus, increased amounts of GDNF in postsynaptic target cells can regulate the number of innervating axons.

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Year:  1998        PMID： 9497292     DOI： 10.1126/science.279.5357.1725

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  67 in total

1.  Expression of GDNF and GDNFR-alpha mRNAs in muscles of patients with motor neuron diseases.

Authors:  M Yamamoto; N Mitsuma; A Inukai; Y Ito; M Li; T Mitsuma; G Sobue
Journal:  Neurochem Res       Date:  1999-06       Impact factor: 3.996

2.  Activity-dependent regulation of synaptic clustering in a hippocampal culture system.

Authors:  E T Kavalali; J Klingauf; R W Tsien
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-26       Impact factor: 11.205

Review 3.  Peripheral nerve regeneration and neurotrophic factors.

Authors:  G Terenghi
Journal:  J Anat       Date:  1999-01       Impact factor: 2.610

4.  Neuregulin expression at neuromuscular synapses is modulated by synaptic activity and neurotrophic factors.

Authors:  Jeffrey A Loeb; Abdelkrim Hmadcha; Gerald D Fischbach; Susan J Land; Vaagn L Zakarian
Journal:  J Neurosci       Date:  2002-03-15       Impact factor: 6.167

Review 5.  Regulation of neurotrophin signaling in aging sensory and motoneurons: dissipation of target support?

Authors:  B Ulfhake; E Bergman; E Edstrom; B T Fundin; H Johnson; S Kullberg; Y Ming
Journal:  Mol Neurobiol       Date:  2000-06       Impact factor: 5.590

6.  Activity-driven synapse elimination leads paradoxically to domination by inactive neurons.

Authors:  M J Barber; J W Lichtman
Journal:  J Neurosci       Date:  1999-11-15       Impact factor: 6.167

Review 7.  Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury.

Authors:  J Gordon Boyd; Tessa Gordon
Journal:  Mol Neurobiol       Date:  2003-06       Impact factor: 5.590

8.  Differential effects of RET and TRKB on axonal branching and survival of parasympathetic neurons.

Authors:  Julie Simpson; Julie Keefe; Rae Nishi
Journal:  Dev Neurobiol       Date:  2012-07-20       Impact factor: 3.964

9.  New roles for glial cell line-derived neurotrophic factor and neurturin: involvement in hair cycle control.

Authors:  N V Botchkareva; V A Botchkarev; P Welker; M Airaksinen; W Roth; P Suvanto; S Müller-Röver; I M Hadshiew; C Peters; R Paus
Journal:  Am J Pathol       Date:  2000-03       Impact factor: 4.307

10.  Glial cell line-derived neurotrophic factor (GDNF) expression and NMJ plasticity in skeletal muscle following endurance exercise.

Authors:  A M Gyorkos; M J McCullough; J M Spitsbergen
Journal:  Neuroscience       Date:  2013-11-08       Impact factor: 3.590
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