OBJECTIVE: To investigate the clinical characteristics of uterine myomas with cytogenetic rearrangements. DESIGN: Comparative study of myomas with normal and abnormal karyotype. SETTING: University hospital. PATIENTS: Premenopausal, GnRH-agonist (GnRH-a) treated and menopausal patients. INTERVENTIONS: Myomectomy or hysterectomy. MAIN OUTCOME MEASURES: Karyotype analysis and clinical characteristics. RESULTS: Clonal abnormalities occurred in 29% of uterine myomas but were not related to the age of the patient or, in untreated menopausal patients, to the size of the myoma. In GnRH-a treated and menopausal women, 48% of the myomas larger than 4 cm were associated with clonal abnormalities. Submucous myomas had significantly fewer clonal abnormalities (12%) than subserosal (29%) or intramural myomas (35%). CONCLUSIONS: The data support the hypothesis that cytogenetic rearrangements in uterine myomas are associated with loss of steroid hormones dependency and alter the growth potential of the tumor.
OBJECTIVE: To investigate the clinical characteristics of uterine myomas with cytogenetic rearrangements. DESIGN: Comparative study of myomas with normal and abnormal karyotype. SETTING: University hospital. PATIENTS: Premenopausal, GnRH-agonist (GnRH-a) treated and menopausal patients. INTERVENTIONS: Myomectomy or hysterectomy. MAIN OUTCOME MEASURES: Karyotype analysis and clinical characteristics. RESULTS:Clonal abnormalities occurred in 29% of uterine myomas but were not related to the age of the patient or, in untreated menopausal patients, to the size of the myoma. In GnRH-a treated and menopausal women, 48% of the myomas larger than 4 cm were associated with clonal abnormalities. Submucous myomas had significantly fewer clonal abnormalities (12%) than subserosal (29%) or intramural myomas (35%). CONCLUSIONS: The data support the hypothesis that cytogenetic rearrangements in uterine myomas are associated with loss of steroid hormones dependency and alter the growth potential of the tumor.
Authors: Jennelle C Hodge; Tae-Min Kim; Jonathan M Dreyfuss; Priya Somasundaram; Nicole C Christacos; Marissa Rousselle; Bradley J Quade; Peter J Park; Elizabeth A Stewart; Cynthia C Morton Journal: Hum Mol Genet Date: 2012-02-17 Impact factor: 6.150
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Authors: Gary Levy; Micah J Hill; Stephanie Beall; Shvetha M Zarek; James H Segars; William H Catherino Journal: J Assist Reprod Genet Date: 2012-05-15 Impact factor: 3.412
Authors: Megan M McGuire; Alexander Yatsenko; Lori Hoffner; Mirka Jones; Urvashi Surti; Aleksandar Rajkovic Journal: PLoS One Date: 2012-03-12 Impact factor: 3.240