Literature DB >> 9496194

Treatment of congenital lactic acidosis with dichloroacetate.

P W Stacpoole1, C L Barnes, M D Hurbanis, S L Cannon, D S Kerr.   

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Year:  1997        PMID： 9496194      PMCID： PMC1717417          DOI： 10.1136/adc.77.6.535

Source DB:  PubMed          Journal:  Arch Dis Child        ISSN： 0003-9888            Impact factor:   3.791


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  40 in total

1.  Treatment of lactic acidosis: effects of dichloroacetate on lactate and pyruvate levels in the cerebrospinal fluid.

Authors:  I Okabe; H Kodama; H Shimoizumi; S Kamoshita; S Miyabayashi
Journal:  Eur J Pediatr       Date:  1986-04       Impact factor: 3.183

2.  Lactic acidosis due to pyruvate carboxylase deficiency.

Authors:  J C Haworth; B H Robinson; T L Perry
Journal:  J Inherit Metab Dis       Date:  1981       Impact factor: 4.982

3.  Dichloroacetate as treatment for congenital lactic acidosis.

Authors:  F X Coude; J M Saudubray; F DeMaugre; C Marsac; J P Leroux; C Charpentier
Journal:  N Engl J Med       Date:  1978-12-14       Impact factor: 91.245

4.  Dichloroacetate in the treatment of congenital lactic acidosis.

Authors:  A Aynsley-Green; A M Weindling; G Soltész; B Ross; P A Jenkins
Journal:  J Inherit Metab Dis       Date:  1984       Impact factor: 4.982

5.  Brief treatment with dichloroacetate does not modify suspected subacute necrotizing encephalomyelitis.

Authors:  O B Evans; P W Stacpoole
Journal:  Ann Neurol       Date:  1980-12       Impact factor: 10.422

6.  Partial pyruvate decarboxylase deficiency with profound lactic acidosis and hyperammonemia: responses to dichloroacetate and benzoate.

Authors:  K McCormick; R M Viscardi; B Robinson; J Heininger
Journal:  Am J Med Genet       Date:  1985-10

7.  Ketonic diet in the management of pyruvate dehydrogenase deficiency.

Authors:  R E Falk; S D Cederbaum; J P Blass; G E Gibson; R A Kark; R E Carrel
Journal:  Pediatrics       Date:  1976-11       Impact factor: 7.124

8.  Lactic acidosis, neurological deterioration and compromised cellular pyruvate oxidation due to a defect in the reoxidation of cytoplasmically generated NADH.

Authors:  B H Robinson; J Taylor; B Francois; A L Beaudet; D F Peterson
Journal:  Eur J Pediatr       Date:  1983-04       Impact factor: 3.183

9.  Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids.

Authors:  S Whitehouse; R H Cooper; P J Randle
Journal:  Biochem J       Date:  1974-09       Impact factor: 3.857

10.  Mitochondrial cytochrome deficiency presenting as a myopathy with hypotonia, external ophthalmoplegia, and lactic acidosis in an infant and as fatal hepatopathy in a second cousin.

Authors:  R N Boustany; J R Aprille; J Halperin; H Levy; G R DeLong
Journal:  Ann Neurol       Date:  1983-10       Impact factor: 10.422
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  28 in total

1.  Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors.

Authors:  Shih-Chia Tso; Mingliang Lou; Cheng-Yang Wu; Wen-Jun Gui; Jacinta L Chuang; Lorraine K Morlock; Noelle S Williams; R Max Wynn; Xiangbing Qi; David T Chuang
Journal:  J Med Chem       Date:  2017-01-31       Impact factor: 7.446

2.  Why are there no proven therapies for genetic mitochondrial diseases?

Authors:  Peter W Stacpoole
Journal:  Mitochondrion       Date:  2011-05-13       Impact factor: 4.160

Review 3.  Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.

Authors:  Margaret O James; Stephan C Jahn; Guo Zhong; Marci G Smeltz; Zhiwei Hu; Peter W Stacpoole
Journal:  Pharmacol Ther       Date:  2016-10-19       Impact factor: 12.310

4.  Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children.

Authors:  Naveen Mangal; Margaret O James; Peter W Stacpoole; Stephan Schmidt
Journal:  J Clin Pharmacol       Date:  2017-09-15       Impact factor: 3.126

5.  Structure-guided development of specific pyruvate dehydrogenase kinase inhibitors targeting the ATP-binding pocket.

Authors:  Shih-Chia Tso; Xiangbing Qi; Wen-Jun Gui; Cheng-Yang Wu; Jacinta L Chuang; Ingrid Wernstedt-Asterholm; Lorraine K Morlock; Kyle R Owens; Philipp E Scherer; Noelle S Williams; Uttam K Tambar; R Max Wynn; David T Chuang
Journal:  J Biol Chem       Date:  2013-12-19       Impact factor: 5.157

6.  An animal model of PDH deficiency using AAV8-siRNA vector-mediated knockdown of pyruvate dehydrogenase E1α.

Authors:  Carolyn Ojano-Dirain; Lyudmyla G Glushakova; Li Zhong; Sergei Zolotukhin; Nicholas Muzyczka; Arun Srivastava; Peter W Stacpoole
Journal:  Mol Genet Metab       Date:  2010-07-15       Impact factor: 4.797

7.  The temporal relationship between glycogen phosphorylase and activation of the pyruvate dehydrogenase complex during adrenaline infusion in resting canine skeletal muscle.

Authors:  Paul A Roberts; Susan J G Loxham; Simon M Poucher; Dumitru Constantin-Teodosiu; Paul L Greenhaff
Journal:  J Physiol       Date:  2002-11-15       Impact factor: 5.182

8.  Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo.

Authors:  Yoshiaki Itoh; Takanori Esaki; Kazuaki Shimoji; Michelle Cook; Mona J Law; Elaine Kaufman; Louis Sokoloff
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-31       Impact factor: 11.205

9.  Long-term safety of dichloroacetate in congenital lactic acidosis.

Authors:  Monica Abdelmalak; Alicia Lew; Ryan Ramezani; Albert L Shroads; Bonnie S Coats; Taimour Langaee; Meena N Shankar; Richard E Neiberger; S H Subramony; Peter W Stacpoole
Journal:  Mol Genet Metab       Date:  2013-04-06       Impact factor: 4.797

10.  Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate.

Authors:  Peter W Stacpoole; Lesa R Gilbert; Richard E Neiberger; Paul R Carney; Edward Valenstein; Douglas W Theriaque; Jonathan J Shuster
Journal:  Pediatrics       Date:  2008-04-14       Impact factor: 7.124
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