| Literature DB >> 9495246 |
M Jurk1, E Kremmer, U Schwarz, R Förster, E L Winnacker.
Abstract
The MAGE-11 gene belongs to a family whose products were identified first in tumor tissue. The MAGE-11 gene product has not been characterized in detail. We have isolated MAGE-11 cDNA from HeLa cells and confirmed the presence of MAGE-11 protein and of at least 2 other MAGE proteins (MAGE-1 and MAGE-3) in this cell line. Monoclonal antibodies (MAbs), obtained by using a GST-MAGE-11 fusion protein, detect MAGE-11 protein in HeLa cells as a 48 kDa protein. In contrast to other known proteins of the MAGE family, MAGE-11 is found mainly in the nucleus. Immunoprecipitation out of whole-cell extracts from different species reveals that MAGE-11 protein is highly conserved among mammalian cells, suggesting a conserved and important function.Entities:
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Year: 1998 PMID： 9495246 DOI： 10.1002/(sici)1097-0215(19980302)75:5<762::aid-ijc16>3.0.co;2-8
Source DB: PubMed Journal: Int J Cancer ISSN： 0020-7136 Impact factor: 7.396