Literature DB >> 949501

Desulphation of heparin by mice and guinea pig leukocytes.

I Fabian, I Bleiberg, M Aronson.   

Abstract

Leukocytes from mice and guinea pigs were tested for their sulphate-splitting activity on heparin. Mouse macrophages showed the highest degrading activity while mouse neutrophils and lymphocytes showed only a week degrading activity. Mouse macrophages maintained in tissue culture were also found to degrade heparin, the amount of sulphate released increasing with time up to 96 h. Spleen extracts were found to neutralize the anticoagulatory activity of heparin.

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Year:  1976        PMID: 949501     DOI: 10.1016/0304-4165(76)90353-6

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  2 in total

1.  Oxidative degradation of rat mast-cell heparin proteoglycan.

Authors:  D D Metcalfe; H L Thompson; S J Klebanoff; W R Henderson
Journal:  Biochem J       Date:  1990-11-15       Impact factor: 3.857

2.  Cell surface receptors for sulphated polysaccharides: a potential marker for macrophage subsets.

Authors:  A S Chong; C R Parish
Journal:  Immunology       Date:  1986-06       Impact factor: 7.397

  2 in total

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