Literature DB >> 9493899

Inhibition of shear-induced platelet aggregation by Chinese herbal medicines.

F L Liao1, B Li.   

Abstract

Shear-induced platelet aggregation (SIPA) plays an important role in vascular diseases. In this study, SIPA was generated by a computerized cone-plate apparatus. Six compounds from Chinese herbal medicine were selected for in vitro and in vivo tests. Rabbit and rat were involved in the tests accordingly. Ligustrazine hydrochloridi appeared to be most effective for inhibition of SIPA. The inhibition rate of SIPA reached 44.2% (p < 0.01) for an in vitro concentration of 1 mg/ml, and 46.1% (p < 0.01) for an in vivo dose of 50 mg/kg.

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Year:  1997        PMID： 9493899

Source DB:  PubMed          Journal:  Clin Hemorheol Microcirc        ISSN： 1386-0291            Impact factor:   2.375


  3 in total

1.  Platelet P2Y₁₂ receptors are involved in the haemostatic effect of notoginsenoside Ft1, a saponin isolated from Panax notoginseng.

Authors:  B Gao; L Huang; H Liu; H Wu; E Zhang; L Yang; X Wu; Z Wang
Journal:  Br J Pharmacol       Date:  2014-01       Impact factor: 8.739

2.  Topical Yunnan Baiyao administration as an adjunctive therapy for bleeding complications in adolescents with advanced cancer.

Authors:  E J Ladas; J B Karlik; D Rooney; K Taromina; D H Ndao; L Granowetter; K M Kelly
Journal:  Support Care Cancer       Date:  2012-10-04       Impact factor: 3.603

Review 3.  Updates on the clinical evidenced herb-warfarin interactions.

Authors:  Beikang Ge; Zhen Zhang; Zhong Zuo
Journal:  Evid Based Complement Alternat Med       Date:  2014-03-18       Impact factor: 2.629
  3 in total

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