Literature DB >> 9493855

Effects of VIP and related peptides on airway mucus secretion from isolated rat trachea.

U Wagner1, D Bredenbröker, B Storm, B Tackenberg, H C Fehmann, P von Wichert.   

Abstract

Vasoactive intestinal polypeptide (VIP) is known as an important regulator of airway function. It has been suggested that VIP is involved in the pathogenesis of asthma due to its relaxant effects on smooth muscles. The present study was designed to characterize the effects of the peptides of the VIP family on airway mucus secretion. The peptides VIP, PHI, PACAP-27, PACAP-38, GLP-I, exendin-4, helodermin, helospectin I and helospectin II were investigated using isolated rat trachea. Data show that PACAP-27 is the most potent stimulator of airway mucus secretion (225% stimulation). The rank order of potency was PACAP-27 > VIP > helospectin II > PHI > exendin-4 = helodermin = helospectin I = PACAP-38. The addition of the protease inhibitor thiorphan enhanced the effects of PHI and helodermin, but not of the other peptides. These data show that the peptides of the VIP family stimulate airway mucus secretion differently.

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Year:  1998        PMID： 9493855     DOI： 10.1016/s0196-9781(97)00257-x

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  9 in total

1.  Distribution of tracheal and laryngeal mucous glands in some rodents and the rabbit.

Authors:  J H Widdicombe; L L Chen; H Sporer; H K Choi; I S Pecson; S J Bastacky
Journal:  J Anat       Date:  2001-02       Impact factor: 2.610

2.  Effect of vasoactive intestinal peptide (VIP)-related peptides on cholinergic neurogenic and direct mucus secretion in ferret trachea in vitro.

Authors:  Y C Liu; A M Khawaja; D F Rogers
Journal:  Br J Pharmacol       Date:  1999-11       Impact factor: 8.739

3.  cAMP-activated Ca2+ signaling is required for CFTR-mediated serous cell fluid secretion in porcine and human airways.

Authors:  Robert J Lee; J Kevin Foskett
Journal:  J Clin Invest       Date:  2010-08-25       Impact factor: 14.808

4.  Neuroregulation by vasoactive intestinal peptide (VIP) of mucus secretion in ferret trachea: activation of BK(Ca) channels and inhibition of neurotransmitter release.

Authors:  Y C Liu; H J Patel; A M Khawaja; M G Belvisi; D F Rogers
Journal:  Br J Pharmacol       Date:  1999-01       Impact factor: 8.739

5.  Tear levels of neuropeptides increase after specific allergen challenge in allergic conjunctivitis.

Authors:  Marta Sacchetti; Alessandra Micera; Alessandro Lambiase; Stefania Speranza; Flavio Mantelli; Girolamo Petrachi; Sergio Bonini; Stefano Bonini
Journal:  Mol Vis       Date:  2011-01-07       Impact factor: 2.367

6.  Analysis of airway secretions in a model of sulfur dioxide induced chronic obstructive pulmonary disease (COPD).

Authors:  Ulrich Wagner; Petra Staats; Hans-Christoph Fehmann; Axel Fischer; Tobias Welte; David A Groneberg
Journal:  J Occup Med Toxicol       Date:  2006-06-07       Impact factor: 2.646

Review 7.  Beneficial Influence of Exendin-4 on Specific Organs and Mechanisms Favourable for the Elderly with Concomitant Obstructive Lung Diseases.

Authors:  Magdalena Figat; Grzegorz Kardas; Piotr Kuna; Michał G Panek
Journal:  Brain Sci       Date:  2022-08-17

8.  Glucagon Like Peptide-1 (GLP-1) Modulates OVA-Induced Airway Inflammation and Mucus Secretion Involving a Protein Kinase A (PKA)-Dependent Nuclear Factor-κB (NF-κB) Signaling Pathway in Mice.

Authors:  Tao Zhu; Xiao-Ling Wu; Wei Zhang; Min Xiao
Journal:  Int J Mol Sci       Date:  2015-08-26       Impact factor: 5.923

Review 9.  Protective Effects of PACAP in Peripheral Organs.

Authors:  Denes Toth; Edina Szabo; Andrea Tamas; Tamas Juhasz; Gabriella Horvath; Eszter Fabian; Balazs Opper; Dora Szabo; Grazia Maugeri; Agata G D'Amico; Velia D'Agata; Viktoria Vicena; Dora Reglodi
Journal:  Front Endocrinol (Lausanne)       Date:  2020-07-14       Impact factor: 5.555
  9 in total

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