Literature DB >> 949333

Inhibition of acetylcholinesterase by derivatives of 1,3,2-dioxaphosphorinane 2-oxide.

D B Coult.   

Abstract

Cholinesterases are inhibited by 2-fluoro-1,3,2-dioxaphosphorinane 2-oxide by a mechanism that involves a slow association step followed by a very slow phosphorylation step. No phosphorylation step was observed for the interaction between acetylcholinesterase and 2-S-[2'-(NN-diethylamino)ethyl]thio-1,3,2-dioxaphosphorinane 2-oxide.

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Year:  1976        PMID： 949333      PMCID： PMC1172899          DOI： 10.1042/bj1550717

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  5 in total

1.  DI-(2-CHLOROETHYL) ARYL PHOSPHATES. A STUDY OF THEIR REACTION WITH B-ESTERASES, AND OF THE GENETIC CONTROL OF THEIR HYDROLYSIS IN SHEEP.

Authors:  R M LEE
Journal:  Biochem Pharmacol       Date:  1964-12       Impact factor: 5.858

2.  A new and rapid colorimetric determination of acetylcholinesterase activity.

Authors:  G L ELLMAN; K D COURTNEY; V ANDRES; R M FEATHER-STONE
Journal:  Biochem Pharmacol       Date:  1961-07       Impact factor: 5.858

3.  Inhibition of cholinesterase by 1,3,2-dioxaphosphorinane 2-oxide derivatives.

Authors:  Y Ashani; S L Snyder; I B Wilson
Journal:  Biochemistry       Date:  1972-09-12       Impact factor: 3.162

4.  The acute toxicity of dichloroalkyl aryl phosphates in relation to chemical structure.

Authors:  W R Pickering; J C Malone
Journal:  Biochem Pharmacol       Date:  1967-07-07       Impact factor: 5.858

5.  Reactivity of some 2-p-nitrophenoxy-1,3,2-dioxaphospholane 2-oxides and -dioxaphosphorinane 2-oxides.

Authors:  T R Fukuto; R L Metcalf
Journal:  J Med Chem       Date:  1965-11       Impact factor: 7.446
  5 in total
  1 in total

1.  Formation of an unstable covalent intermediate during the inhibition of electric-eel acetylcholinesterase with 1,3,2-dioxaphosphorinane 2-oxides.

Authors:  Y Ashani; H Leader
Journal:  Biochem J       Date:  1979-03-01       Impact factor: 3.857
  1 in total

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