Literature DB >> 949314

Is a Schiff base involved in the mechanism of the delta4-3-oxo steroid 5alpha- or 5beta-reductases from mammalian liver?

D C Wilton.   

Abstract

The saturation of the delta4-double bond of delta4-3-oxo steroids by the mammalian 5alpha- or 5beta-reductases is by an enzyme mechanism that does not involve a Schiff-base intermediate.

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Year:  1976        PMID： 949314      PMCID： PMC1172870          DOI： 10.1042/bj1550487

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  9 in total

1.  The substrate activation in some pyridine nucleotide linked enzymic reactions. The conversion of desmosterol into cholesterol.

Authors:  I A Watkinson; D C Wilton; A D Rahimtula; M M Akhtar
Journal:  Eur J Biochem       Date:  1971-11-11

Review 2.  Substrate activation in pyridine nucleotide-linked reactions: illustrations from the steroid field.

Authors:  M Akhtar; D C Wilton; I A Watkinson; A D Rahimtula
Journal:  Proc R Soc Lond B Biol Sci       Date:  1972-02-15

3.  The biological conversion of 7-dehydrocholesterol into cholesterol and comments on the reduction of double bonds.

Authors:  D C Wilton; K A Munday; S J Skinner; M Akhtar
Journal:  Biochem J       Date:  1968-02       Impact factor: 3.857

Review 4.  Factors regulating the metabolism of steroids.

Authors:  H Schriefers
Journal:  Vitam Horm       Date:  1967       Impact factor: 3.421

5.  Oxygen-18 exchange reactions in steroidal ketones. Determination of relative rates of incorporation by gas chromatography-mass spectrometry.

Authors:  A M Lawson; F A Leemans; J A McCloskey
Journal:  Steroids       Date:  1969-11       Impact factor: 2.668

6.  The mechanism of the bond forming events in pyridine nucleotide linked oxidoreductases. Studies with epoxide inhibitors of lactic dehydrogenase and beta-hydroxybutyrate dehydrogenase.

Authors:  D P Bloxham; I G Giles; D C Wilton; M Akhtar
Journal:  Biochemistry       Date:  1975-05-20       Impact factor: 3.162

7.  The formation and reduction of the 14,15-double bond in cholesterol biosynthesis.

Authors:  I A Watkinson; D C Wilton; K A Munday; M Akhtar
Journal:  Biochem J       Date:  1971-01       Impact factor: 3.857

8.  Mechamism and stereochemistry of the enzymatic conversion of a delta 4-3-oxosteroid into a 3-oxo-5alpha-steroid.

Authors:  I Björkhem
Journal:  Eur J Biochem       Date:  1969-04

9.  Enzymatic conversion of a delta-4-3-ketosteroid into a 3-alpha-hydroxy-5-beta steroid: mechanism and stereochemistry of hydrogen transfer from NADPH. Bile acids and steroids 190.

Authors:  O Berséus; L Björkhem
Journal:  Eur J Biochem       Date:  1967-11
  9 in total
  1 in total

1.  Maleylacetate reductase of Pseudomonas sp. strain B13: specificity of substrate conversion and halide elimination.

Authors:  S R Kaschabek; W Reineke
Journal:  J Bacteriol       Date:  1995-01       Impact factor: 3.490
  1 in total

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