Literature DB >> 9491765

Trypanocidal effects of gallic acid and related compounds.

T Koide1, M Nose, M Inoue, Y Ogihara, Y Yabu, N Ohta.   

Abstract

Gallic acid (3,4,5-trihydroxybenzoic acid) is a naturally abundant plant phenolic compound and it is well known as a component of hydrolyzable tannins. We report here that gallic acid and related compounds have trypanocidal activity against Trypanosoma brucei brucei (GUTat 3.1) in both the long slender bloodstream forms and the procyclic forms, in vitro. LD50 values of gallic acid are 46.96 +/- 1.28 microM for bloodstream forms and 30.02 +/- 3.49 for procyclic forms, respectively. A study of structurally related compounds suggested that the pyrogallol moiety could be responsible for this activity.

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Year:  1998        PMID： 9491765     DOI： 10.1055/s-2006-957360

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  6 in total

1.  Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies.

Authors:  Deniz Tasdemir; Marcel Kaiser; Reto Brun; Vanessa Yardley; Thomas J Schmidt; Fatma Tosun; Peter Rüedi
Journal:  Antimicrob Agents Chemother       Date:  2006-04       Impact factor: 5.191

2.  In vitro anti-Trichomonas vaginalis activity of Pistacia lentiscus mastic and Ocimum basilicum essential oil.

Authors:  Hayam Mohamed Ezz Eldin; Abeer Fathy Badawy
Journal:  J Parasit Dis       Date:  2013-10-26

3.  Novel Gallate Triphenylphosphonium Derivatives with Potent Antichagasic Activity.

Authors:  Leonel A Cortes; Lorena Castro; Bárbara Pesce; Juan D Maya; Jorge Ferreira; Vicente Castro-Castillo; Eduardo Parra; José A Jara; Rodrigo López-Muñoz
Journal:  PLoS One       Date:  2015-08-28       Impact factor: 3.240

4.  Bumble bee parasite strains vary in resistance to phytochemicals.

Authors:  Evan C Palmer-Young; Ben M Sadd; Philip C Stevenson; Rebecca E Irwin; Lynn S Adler
Journal:  Sci Rep       Date:  2016-11-24       Impact factor: 4.379

Review 5.  Antiparasitic activity in Asteraceae with special attention to ethnobotanical use by the tribes of Odisha, India.

Authors:  Sujogya Kumar Panda; Walter Luyten
Journal:  Parasite       Date:  2018-03-12       Impact factor: 3.000

6.  In vitro effects of Blepharocalyx salicifolius (H.B.K.) O. Berg on the viability of Echinococcus ortleppi protoscoleces.

Authors:  Charlise Bolson Noal; Danieli Urach Monteiro; Thiele Faccim de Brum; Jessica Emmanouilidis; Regis Adriel Zanette; Ademir Farias Morel; Eliza Beti de Cassia Stefanon; Marina Frosi; Mario Luiz de la Rue
Journal:  Rev Inst Med Trop Sao Paulo       Date:  2017-08-03       Impact factor: 1.846
  6 in total

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