| Literature DB >> 9490024 |
D J Chang1, T K Chang, S S Yamanishi, F H Salazar, A H Kosaka, R Khare, S Bhakta, J R Jasper, I S Shieh, J D Lesnick, A P Ford, D V Daniels, R M Eglen, D E Clarke, C Bach, H W Chan.
Abstract
We have isolated and characterized from human prostate novel splice variants of the human alpha1A-adrenoceptor, several of which generate truncated products and one isoform, alpha(1A-4), which has the identical splice site as the three previously described isoforms. Long-PCR on human genomic DNA showed that the alpha(1A-4) exon is located between those encoding the alpha(1A-1) and alpha(1A-3) variants. CHO-K1 cells stably expressing alpha(1A-4) showed ligand binding properties similar to those of the other functional isoforms as well as agonist-stimulated inositol phosphate accumulation. Quantitative PCR analyses revealed that alpha(1A-4) is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.Entities:
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Year: 1998 PMID： 9490024 DOI： 10.1016/s0014-5793(98)00024-6
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124