Literature DB >> 9488439

Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse.

V Korinek1, N Barker, K Willert, M Molenaar, J Roose, G Wagenaar, M Markman, W Lamers, O Destree, H Clevers.   

Abstract

Tcf transcription factors interact with beta-catenin and Armadillo to mediate Wnt/Wingless signaling. We now report the characterization of genes encoding two murine members of the Tcf family, mTcf-3 and mTcf-4. mTcf-3 mRNA is ubiquitously present in embryonic day 6.5 (E6.5) mouse embryos but gradually disappears over the next 3 to 4 days. mTcf-4 expression occurs first at E10.5 and is restricted to di- and mesencephalon and the intestinal epithelium during embryogenesis. The mTcf-3 and mTcf-4 proteins bind a canonical Tcf DNA motif and can complex with the transcriptional coactivator beta-catenin. Overexpression of Wnt-1 in a mammary epithelial cell line leads to the formation of a nuclear complex between beta-catenin and Tcf proteins and to Tcf reporter gene transcription. These data demonstrate a direct link between Wnt stimulation and beta-catenin/Tcf transcriptional activation and imply a role for mTcf-3 and -4 in early Wnt-driven developmental decisions in the mouse embryo.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9488439      PMCID： PMC108837          DOI： 10.1128/MCB.18.3.1248

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  44 in total

1.  Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

Authors:  M Gossen; H Bujard
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

2.  Wnt signalling required for expansion of neural crest and CNS progenitors.

Authors:  M Ikeya; S M Lee; J E Johnson; A P McMahon; S Takada
Journal:  Nature       Date:  1997-10-30       Impact factor: 49.962

Review 3.  A versatile transcriptional effector of Wingless signaling.

Authors:  R Nusse
Journal:  Cell       Date:  1997-05-02       Impact factor: 41.582

4.  Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4.

Authors:  K Stark; S Vainio; G Vassileva; A P McMahon
Journal:  Nature       Date:  1994-12-15       Impact factor: 49.962

5.  Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development.

Authors:  K R Thomas; M R Capecchi
Journal:  Nature       Date:  1990-08-30       Impact factor: 49.962

6.  Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.

Authors:  V Korinek; N Barker; P J Morin; D van Wichen; R de Weger; K W Kinzler; B Vogelstein; H Clevers
Journal:  Science       Date:  1997-03-21       Impact factor: 47.728

7.  LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic.

Authors:  J Riese; X Yu; A Munnerlyn; S Eresh; S C Hsu; R Grosschedl; M Bienz
Journal:  Cell       Date:  1997-03-21       Impact factor: 41.582

8.  An HMG-box-containing T-cell factor required for thymocyte differentiation.

Authors:  S Verbeek; D Izon; F Hofhuis; E Robanus-Maandag; H te Riele; M van de Wetering; M Oosterwegel; A Wilson; H R MacDonald; H Clevers
Journal:  Nature       Date:  1995-03-02       Impact factor: 49.962

9.  Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds.

Authors:  B A Parr; M J Shea; G Vassileva; A P McMahon
Journal:  Development       Date:  1993-09       Impact factor: 6.868

10.  Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling.

Authors:  N Funayama; F Fagotto; P McCrea; B M Gumbiner
Journal:  J Cell Biol       Date:  1995-03       Impact factor: 10.539
View more
  117 in total

1.  Epithelial stem cell repertoire in the gut: clues to the origin of cell lineages, proliferative units and cancer.

Authors:  N A Wright
Journal:  Int J Exp Pathol       Date:  2000-04       Impact factor: 1.925

2.  Inhibition of Tcf3 binding by I-mfa domain proteins.

Authors:  L Snider; H Thirlwell; J R Miller; R T Moon; M Groudine; S J Tapscott
Journal:  Mol Cell Biol       Date:  2001-03       Impact factor: 4.272

3.  T cell factor-activated transcription is not sufficient to induce anchorage-independent growth of epithelial cells expressing mutant beta-catenin.

Authors:  A I Barth; D B Stewart; W J Nelson
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-27       Impact factor: 11.205

4.  Characterization and functional analysis of the 5'-flanking promoter region of the mouse Tcf3 gene.

Authors:  Nina Solberg; Ondrej Machon; Stefan Krauss
Journal:  Mol Cell Biochem       Date:  2011-09-21       Impact factor: 3.396

5.  Molecular basis for Flk1 expression in hemato-cardiovascular progenitors in the mouse.

Authors:  Hiroyuki Ishitobi; Asami Wakamatsu; Fang Liu; Takuya Azami; Michito Hamada; Ken Matsumoto; Hiroshi Kataoka; Makoto Kobayashi; Kyunghee Choi; Shin-ichi Nishikawa; Satoru Takahashi; Masatsugu Ema
Journal:  Development       Date:  2011-11-09       Impact factor: 6.868

6.  Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expression.

Authors:  J Galceran; S C Hsu; R Grosschedl
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-10       Impact factor: 11.205

7.  Dehydroepiandrosterone administration or G{alpha}q overexpression induces {beta}-catenin/T-Cell factor signaling and growth via increasing association of estrogen receptor-{beta}/Dishevelled2 in androgen-independent prostate cancer cells.

Authors:  Xunxian Liu; Julia T Arnold; Marc R Blackman
Journal:  Endocrinology       Date:  2010-02-22       Impact factor: 4.736

8.  Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium.

Authors:  Jun Kimura; Yoko Suda; Daisuke Kurokawa; Zakir M Hossain; Miwa Nakamura; Maiko Takahashi; Akemi Hara; Shinichi Aizawa
Journal:  J Neurosci       Date:  2005-05-25       Impact factor: 6.167

9.  Ligand activation of the androgen receptor downregulates E-cadherin-mediated cell adhesion and promotes apoptosis of prostatic cancer cells.

Authors:  Joanna Nightingale; Khurram S Chaudhary; Paul D Abel; Andrew P Stubbs; Hanna M Romanska; Stephen E Mitchell; Gordon W H Stamp; El-Nasir Lalani
Journal:  Neoplasia       Date:  2003 Jul-Aug       Impact factor: 5.715

10.  alpha-Catenin overrides Src-dependent activation of beta-catenin oncogenic signaling.

Authors:  Landon J Inge; Sigrid A Rajasekaran; Daniel Wolle; Sonali P Barwe; Sergey Ryazantsev; Charles M Ewing; William B Isaacs; Ayyappan K Rajasekaran
Journal:  Mol Cancer Ther       Date:  2008-06       Impact factor: 6.261
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.