| Literature DB >> 9488199 |
Abstract
Calcium channel blockers have been studied widely for their potential ability to retard or even reverse atherosclerosis. Several potential cellular mechanisms have been proposed, including interactions with vascular smooth muscle cells: migration, inhibition of proliferation, or both. This paper reviews some of the signaling events involved in smooth muscle cell migration, including changes in intracellular calcium, and the inhibition of cell migration by calcium channel blockers. Finally, there is a discussion of preliminary experiments on human vascular smooth muscle cell migration using amlodipine.Entities:
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Year: 1997 PMID: 9488199 DOI: 10.1016/s0167-5273(97)00245-3
Source DB: PubMed Journal: Int J Cardiol ISSN: 0167-5273 Impact factor: 4.164